3fke

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:49, 21 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3fke.png|left|200px]]
 
-
<!--
+
==Structure of the Ebola VP35 Interferon Inhibitory Domain==
-
The line below this paragraph, containing "STRUCTURE_3fke", creates the "Structure Box" on the page.
+
<StructureSection load='3fke' size='340' side='right'caption='[[3fke]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3fke]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_-_Mayinga,_Zaire,_1976 Ebola virus - Mayinga, Zaire, 1976]. The October 2014 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ebola Virus Proteins'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2014_10 10.2210/rcsb_pdb/mom_2014_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FKE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fke OCA], [https://pdbe.org/3fke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fke RCSB], [https://www.ebi.ac.uk/pdbsum/3fke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fke ProSAT]</span></td></tr>
-
{{STRUCTURE_3fke| PDB=3fke | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Structure of the Ebola VP35 Interferon Inhibitory Domain===
+
[https://www.uniprot.org/uniprot/VP35_EBOZM VP35_EBOZM] Acsts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR.<ref>PMID:9971816</ref> <ref>PMID:11027311</ref> <ref>PMID:12829834</ref> <ref>PMID:16495261</ref> <ref>PMID:17065211</ref>
-
 
+
== References ==
-
 
+
<references/>
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_19122151}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19122151 is the PubMed ID number.
+
[[Category: Ebola Virus Proteins]]
-
-->
+
[[Category: Ebola virus - Mayinga, Zaire, 1976]]
-
{{ABSTRACT_PUBMED_19122151}}
+
[[Category: Large Structures]]
-
 
+
[[Category: RCSB PDB Molecule of the Month]]
-
==About this Structure==
+
[[Category: Amarasinghe GK]]
-
3FKE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FKE OCA].
+
[[Category: Basler CF]]
-
 
+
[[Category: Fulton DB]]
-
==Reference==
+
[[Category: Ginder ND]]
-
<ref group="xtra">PMID:19122151</ref><references group="xtra"/>
+
[[Category: Honzatko RB]]
-
[[Category: Viruses]]
+
[[Category: Leung DW]]
-
[[Category: Amarasinghe, G K.]]
+
[[Category: Nix J]]
-
[[Category: Basler, C F.]]
+
-
[[Category: Fulton, D B.]]
+
-
[[Category: Ginder, N D.]]
+
-
[[Category: Honzatko, R B.]]
+
-
[[Category: Leung, D W.]]
+
-
[[Category: Nix, J.]]
+
-
[[Category: Coiled coil]]
+
-
[[Category: Interferon antiviral system evasion]]
+
-
[[Category: Rna binding domain]]
+
-
[[Category: Rna binding protein]]
+
-
[[Category: Rna replication]]
+
-
[[Category: Rna-binding]]
+
-
[[Category: Transcription]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 11:20:59 2009''
+

Current revision

Structure of the Ebola VP35 Interferon Inhibitory Domain

PDB ID 3fke

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fke"
Personal tools