3eas

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{{Seed}}
 
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[[Image:3eas.png|left|200px]]
 
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==Novel dimerization motif in the DEAD box RNA helicase Hera: form 1, complete dimer, asymmetric==
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The line below this paragraph, containing "STRUCTURE_3eas", creates the "Structure Box" on the page.
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<StructureSection load='3eas' size='340' side='right'caption='[[3eas]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3eas]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3EAS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3eas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3eas OCA], [https://pdbe.org/3eas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3eas RCSB], [https://www.ebi.ac.uk/pdbsum/3eas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3eas ProSAT]</span></td></tr>
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{{STRUCTURE_3eas| PDB=3eas | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q72GF3_THET2 Q72GF3_THET2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ea/3eas_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3eas ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DEAD box helicases are involved in nearly all aspects of RNA metabolism. They share a common helicase core, and may comprise additional domains that contribute to RNA binding. The Thermus thermophilus helicase Hera is the first dimeric DEAD box helicase. Crystal structures of Hera fragments reveal a bipartite C-terminal domain with a novel dimerization motif and an RNA-binding module. We provide a first glimpse on the additional RNA-binding module outside the Hera helicase core. The dimerization and RNA-binding domains are connected to the C-terminal RecA domain by a hinge region that confers exceptional flexibility onto the helicase, allowing for different juxtapositions of the RecA-domains in the dimer. Combination of the previously determined N-terminal Hera structure with the C-terminal Hera structures allows generation of a model for the entire Hera dimer, where two helicase cores can work in conjunction on large RNA substrates.
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===Novel dimerization motif in the DEAD box RNA helicase Hera: form 1, complete dimer, asymmetric===
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A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility.,Klostermeier D, Rudolph MG Nucleic Acids Res. 2009 Feb;37(2):421-30. Epub 2008 Dec 2. PMID:19050012<ref>PMID:19050012</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3eas" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19050012}}, adds the Publication Abstract to the page
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*[[Helicase 3D structures|Helicase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19050012 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19050012}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3EAS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3EAS OCA].
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[[Category: Thermus thermophilus HB27]]
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[[Category: Klostermeier D]]
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==Reference==
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[[Category: Rudolph MG]]
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<ref group="xtra">PMID:19050012</ref><references group="xtra"/>
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[[Category: Thermus thermophilus]]
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[[Category: Klostermeier, D.]]
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[[Category: Rudolph, M G.]]
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[[Category: Atp-binding]]
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[[Category: Dead box rna helicase]]
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[[Category: Dimer]]
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[[Category: Helicase]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 11:22:08 2009''
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Current revision

Novel dimerization motif in the DEAD box RNA helicase Hera: form 1, complete dimer, asymmetric

PDB ID 3eas

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