2kd3

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{{Seed}}
 
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[[Image:2kd3.jpg|left|200px]]
 
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==NMR structure of the Wnt modulator protein Sclerostin==
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The line below this paragraph, containing "STRUCTURE_2kd3", creates the "Structure Box" on the page.
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<StructureSection load='2kd3' size='340' side='right'caption='[[2kd3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KD3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kd3 OCA], [https://pdbe.org/2kd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kd3 ProSAT]</span></td></tr>
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{{STRUCTURE_2kd3| PDB=2kd3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SOST_MOUSE SOST_MOUSE] Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.<ref>PMID:19419300</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kd3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kd3 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Sclerostin has been identified as a negative regulator of bone growth. Initially it was considered that Sclerostin performs its regulatory function via acting as a modulator of bone morphogenetic proteins (BMPs) similar to known examples such as Noggin, Chordin, and members of the DAN family. Recent findings, however, show that Sclerostin interferes with the Wnt signaling pathway due to binding to the Wnt co-receptor LRP5 thereby modulating bone growth. As Sclerostin is exclusively produced by osteocytes located in bones, neutralization of its bone-inhibiting functions makes it a highly interesting target for an osteoanabolic therapeutic approach in diseases characterized by bone loss, such as osteoporosis. Despite the huge interest in Sclerostin inhibitors the molecular basis of its function and its interaction with components of the Wnt signaling cascade has remained unclear. Here, we present the NMR structure of murine Sclerostin providing the first insights how Sclerostin might bind to LRP5.
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===NMR structure of the Wnt modulator protein Sclerostin===
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NMR structure of the Wnt modulator protein Sclerostin.,Weidauer SE, Schmieder P, Beerbaum M, Schmitz W, Oschkinat H, Mueller TD Biochem Biophys Res Commun. 2009 Feb 27;380(1):160-5. Epub 2009 Jan 21. PMID:19166819<ref>PMID:19166819</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19166819}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kd3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19166819 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19166819}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2KD3 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD3 OCA].
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==Reference==
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<ref group="xtra">PMID:19166819</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Mueller, T D.]]
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[[Category: Mueller TD]]
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[[Category: Weidauer, S E.]]
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[[Category: Weidauer SE]]
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[[Category: Antagonist of cytokine]]
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[[Category: Protein]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:35:51 2009''
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Current revision

NMR structure of the Wnt modulator protein Sclerostin

PDB ID 2kd3

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