3g0w

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(New page: '''Unreleased structure''' The entry 3g0w is ON HOLD Authors: Nirschl, A.A., Zou, Y., Krystek Junior, S.R., Sutton, J.C., Simpkins, L.M., Lupisella, J.A., Kuhns, J.E., Seethala, R., Gol...)
Current revision (09:51, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3g0w is ON HOLD
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==Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor==
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<StructureSection load='3g0w' size='340' side='right'caption='[[3g0w]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3g0w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G0W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LGB:2-CHLORO-4-{[(1R,3Z,7S,7AS)-7-HYDROXY-1-(TRIFLUOROMETHYL)TETRAHYDRO-1H-PYRROLO[1,2-C][1,3]OXAZOL-3-YLIDENE]AMINO}-3-METHYLBENZONITRILE'>LGB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g0w OCA], [https://pdbe.org/3g0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g0w RCSB], [https://www.ebi.ac.uk/pdbsum/3g0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g0w ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ANDR_RAT ANDR_RAT] Note=Defects in Ar are a cause of androgen insensitivity. Rats with this syndrome are called testicular feminized (TFM).<ref>PMID:2341409</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ANDR_RAT ANDR_RAT] Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (By similarity).<ref>PMID:17181141</ref> <ref>PMID:17008401</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g0/3g0w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g0w ConSurf].
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<div style="clear:both"></div>
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Authors: Nirschl, A.A., Zou, Y., Krystek Junior, S.R., Sutton, J.C., Simpkins, L.M., Lupisella, J.A., Kuhns, J.E., Seethala, R., Golla, R., Sleph, P.G., Beehler, B.C., Grover, G.J., Egan, D., Fura, A., Vyas, V.P., Li, Y.-X., Sack, J.S., Kish, K.F., An, Y., Bryson,
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==See Also==
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*[[Androgen receptor 3D structures|Androgen receptor 3D structures]]
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Description: CRYSTAL STRUCTURE OF THE RAT ANDROGEN RECEPTOR LIGAND BINDING DOMAIN COMPLEX WITH AN N-ARYL-OXAZOLIDIN 2-IMINE INHIBITOR
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== References ==
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 11 12:36:25 2009''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Sack JS]]

Current revision

Crystal structure of the rat androgen receptor ligand binding domain complex with an n-aryl-oxazolidin 2-imine inhibitor

PDB ID 3g0w

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