2w31

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{{Seed}}
 
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[[Image:2w31.png|left|200px]]
 
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==globin domain of Geobacter sulfurreducens globin-coupled sensor==
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The line below this paragraph, containing "STRUCTURE_2w31", creates the "Structure Box" on the page.
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<StructureSection load='2w31' size='340' side='right'caption='[[2w31]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2w31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W31 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_2w31| PDB=2w31 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w31 OCA], [https://pdbe.org/2w31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w31 RCSB], [https://www.ebi.ac.uk/pdbsum/2w31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w31 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q747F6_GEOSL Q747F6_GEOSL]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/2w31_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w31 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Among heme-based sensors, recent phylogenomic and sequence analyses have identified 34 globin coupled sensors (GCS), to which an aerotactic or gene-regulating function has been tentatively ascribed. Here, the structural and biochemical characterization of the globin domain of the GCS from Geobacter sulfurreducens (GsGCS(162)) is reported. A combination of X-ray crystallography (crystal structure at 1.5 A resolution), UV-vis and resonance Raman spectroscopy reveals the ferric GsGCS(162) as an example of bis-histidyl hexa-coordinated GCS. In contrast to the known hexa-coordinated globins, the distal heme-coordination in ferric GsGCS(162) is provided by a His residue unexpectedly located at the E11 topological site. Furthermore, UV-vis and resonance Raman spectroscopy indicated that ferrous deoxygenated GsGCS(162) is a penta-/hexa-coordinated mixture, and the heme hexa-to-penta-coordination transition does not represent a rate-limiting step for carbonylation kinetics. Lastly, electron paramagnetic resonance indicates that ferrous nitrosylated GsGCS(162) is a penta-coordinated species, where the proximal HisF8-Fe bond is severed.
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===GLOBIN DOMAIN OF GEOBACTER SULFURREDUCENS GLOBIN-COUPLED SENSOR===
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HisE11 and HisF8 provide bis-histidyl heme hexa-coordination in the globin domain of Geobacter sulfurreducens globin-coupled sensor.,Pesce A, Thijs L, Nardini M, Desmet F, Sisinni L, Gourlay L, Bolli A, Coletta M, Van Doorslaer S, Wan X, Alam M, Ascenzi P, Moens L, Bolognesi M, Dewilde S J Mol Biol. 2009 Feb 13;386(1):246-60. Epub 2008 Dec 16. PMID:19109973<ref>PMID:19109973</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19109973}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2w31" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19109973 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19109973}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2W31 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W31 OCA].
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==Reference==
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<ref group="xtra">PMID:19109973</ref><references group="xtra"/>
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[[Category: Geobacter sulfurreducens]]
[[Category: Geobacter sulfurreducens]]
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[[Category: Alam, M.]]
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[[Category: Large Structures]]
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[[Category: Ascenzi, P.]]
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[[Category: Alam M]]
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[[Category: Bolli, A.]]
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[[Category: Ascenzi P]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolli A]]
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[[Category: Coletta, M.]]
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[[Category: Bolognesi M]]
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[[Category: Desmet, F.]]
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[[Category: Coletta M]]
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[[Category: Dewilde, S.]]
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[[Category: Desmet F]]
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[[Category: Doorslaer, S Van.]]
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[[Category: Dewilde S]]
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[[Category: Gourlay, L.]]
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[[Category: Gourlay L]]
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[[Category: Moens, L.]]
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[[Category: Moens L]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Pesce, A.]]
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[[Category: Pesce A]]
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[[Category: Sisinni, L.]]
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[[Category: Sisinni L]]
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[[Category: Thijs, L.]]
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[[Category: Thijs L]]
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[[Category: Wan, X.]]
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[[Category: Van Doorslaer S]]
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[[Category: Geobacter sulfurreducen]]
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[[Category: Wan X]]
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[[Category: Globin coupled sensor]]
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[[Category: Hexacoordination]]
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[[Category: Oxygen transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 15 08:45:42 2009''
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Current revision

globin domain of Geobacter sulfurreducens globin-coupled sensor

PDB ID 2w31

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