3fe4

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[[Image:3fe4.png|left|200px]]
 
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==Crystal Structure of Human Carbonic Anhydrase vi==
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The line below this paragraph, containing "STRUCTURE_3fe4", creates the "Structure Box" on the page.
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<StructureSection load='3fe4' size='340' side='right'caption='[[3fe4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fe4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FE4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_3fe4| PDB=3fe4 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fe4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fe4 OCA], [https://pdbe.org/3fe4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fe4 RCSB], [https://www.ebi.ac.uk/pdbsum/3fe4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fe4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAH6_HUMAN CAH6_HUMAN] Reversible hydration of carbon dioxide. Its role in saliva is unknown.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zn(2+)-dependent carbonic anhydrases (CA) catalyse the reversible hydration of carbon dioxide to bicarbonate and participate in diverse physiological processes, hence having manifold therapeutic potentials. Among the 15 human CAs with wide-ranging sub-cellular localisation and kinetic properties, CA VI is the only secretory isoform. The 1.9A crystal structure of the human CA VI catalytic domain reveals a prototypical mammalian CA fold, and a novel dimeric arrangement as compared to previously-reported CA structures. The active site cavity contains a cluster of non-conserved residues that may be involved in ligand binding and have significant implications for developing the next-generation of isoform-specific inhibitors.
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===Crystal Structure of Human Carbonic Anhydrase vi===
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Crystal structure of the secretory isozyme of mammalian carbonic anhydrases CA VI: implications for biological assembly and inhibitor development.,Pilka ES, Kochan G, Oppermann U, Yue WW Biochem Biophys Res Commun. 2012 Mar 16;419(3):485-9. Epub 2012 Feb 14. PMID:22366092<ref>PMID:22366092</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3fe4" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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3FE4 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FE4 OCA].
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*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
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[[Category: Carbonate dehydratase]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith CH]]
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[[Category: Delft, F von.]]
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[[Category: Bountra C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Kochan, G.]]
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[[Category: Kochan G]]
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[[Category: Krysztofinska, E.]]
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[[Category: Krysztofinska E]]
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[[Category: Muniz, J.]]
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[[Category: Muniz J]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Pilka, E S.]]
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[[Category: Pilka ES]]
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[[Category: Roos, A K.]]
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[[Category: Roos AK]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yue WW]]
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[[Category: Yue, W W.]]
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[[Category: Von Delft F]]
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[[Category: Carbonic anhydrase]]
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[[Category: Glycoprotein]]
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[[Category: Lyase]]
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[[Category: Metal binding]]
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[[Category: Metal-binding]]
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[[Category: Polymorphism]]
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[[Category: Secreted]]
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[[Category: Secretion]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 15 08:48:26 2009''
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Current revision

Crystal Structure of Human Carbonic Anhydrase vi

PDB ID 3fe4

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