1d5v

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{{Seed}}
 
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[[Image:1d5v.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)==
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The line below this paragraph, containing "STRUCTURE_1d5v", creates the "Structure Box" on the page.
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<StructureSection load='1d5v' size='340' side='right'caption='[[1d5v]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D5V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d5v OCA], [https://pdbe.org/1d5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d5v RCSB], [https://www.ebi.ac.uk/pdbsum/1d5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d5v ProSAT]</span></td></tr>
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{{STRUCTURE_1d5v| PDB=1d5v | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FOXC2_HUMAN FOXC2_HUMAN] Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:[https://omim.org/entry/153200 153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment.<ref>PMID:11078474</ref> Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:[https://omim.org/entry/153300 153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:[https://omim.org/entry/153400 153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).<ref>PMID:11499682</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FOXC2_HUMAN FOXC2_HUMAN] Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.<ref>PMID:9169153</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d5/1d5v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d5v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Transcription factors of the forkhead type share a highly conserved DNA-binding domain of about 100 amino acid residues. FREAC-11, expressed in adipocytes, belongs to this class. Here, we report on NMR studies that established the three-dimensional structure of the FREAC-11, DNA-binding domain. Although apparent similarities to the structures of other members within the forkhead family are observed, the structure also reveals some remarkable differences. Along with the complementary dynamics, the data provide insight into the fundamentals of sequence specificity within a highly conserved motif.
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===SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)===
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Solution structure and dynamics of the DNA-binding domain of the adipocyte-transcription factor FREAC-11.,van Dongen MJ, Cederberg A, Carlsson P, Enerback S, Wikstrom M J Mol Biol. 2000 Feb 18;296(2):351-9. PMID:10669593<ref>PMID:10669593</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_10669593}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1d5v" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 10669593 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10669593}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1D5V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D5V OCA].
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==Reference==
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<ref group="xtra">PMID:10669593</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Carlsson, P.]]
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[[Category: Large Structures]]
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[[Category: Cederberg, A.]]
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[[Category: Carlsson P]]
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[[Category: Dongen, M J.P van.]]
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[[Category: Cederberg A]]
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[[Category: Enerback, S.]]
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[[Category: Enerback S]]
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[[Category: Wikstrom, M.]]
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[[Category: Wikstrom M]]
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[[Category: Dna-recognition helix]]
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[[Category: Van Dongen MJP]]
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[[Category: Winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 09:57:31 2009''
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Current revision

SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)

PDB ID 1d5v

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