1w9r

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{{Seed}}
 
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[[Image:1w9r.png|left|200px]]
 
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==Solution Structure of Choline Binding Protein A, Domain R2, the Major Adhesin of Streptococcus pneumoniae==
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The line below this paragraph, containing "STRUCTURE_1w9r", creates the "Structure Box" on the page.
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<StructureSection load='1w9r' size='340' side='right'caption='[[1w9r]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1w9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W9R FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w9r OCA], [https://pdbe.org/1w9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w9r RCSB], [https://www.ebi.ac.uk/pdbsum/1w9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w9r ProSAT]</span></td></tr>
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{{STRUCTURE_1w9r| PDB=1w9r | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0H2US50_STRPN A0A0H2US50_STRPN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w9/1w9r_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w9r ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Streptococcus pneumoniae (pneumococcus) remains a significant health threat worldwide, especially to the young and old. While some of the biomolecules involved in pneumococcal pathogenesis are known and understood in mechanistic terms, little is known about the molecular details of bacterium/host interactions. We report here the solution structure of the 'repeated' adhesion domains (domains R1 and R2) of the principal pneumococcal adhesin, choline binding protein A (CbpA). Further, we provide insights into the mechanism by which CbpA binds its human receptor, polymeric immunoglobulin receptor (pIgR). The R domains, comprised of 12 imperfect copies of the leucine zipper heptad motif, adopt a unique 3-alpha-helix, raft-like structure. Each pair of alpha-helices is antiparallel and conserved residues in the loop between Helices 1 and 2 exhibit a novel 'tyrosine fork' structure that is involved in binding pIgR. This and other structural features that we show are conserved in most pneumococcal strains appear to generally play an important role in bacterial adhesion to pIgR. Interestingly, pneumococcus is the only bacterium known to adhere to and invade human cells by binding to pIgR.
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===SOLUTION STRUCTURE OF CHOLINE BINDING PROTEIN A, DOMAIN R2, THE MAJOR ADHESIN OF STREPTOCOCCUS PNEUMONIAE===
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Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae.,Luo R, Mann B, Lewis WS, Rowe A, Heath R, Stewart ML, Hamburger AE, Sivakolundu S, Lacy ER, Bjorkman PJ, Tuomanen E, Kriwacki RW EMBO J. 2005 Jan 12;24(1):34-43. Epub 2004 Dec 16. PMID:15616594<ref>PMID:15616594</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15616594}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1w9r" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15616594 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15616594}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1W9R is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W9R OCA].
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Bjorkman PJ]]
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==Reference==
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[[Category: Hamburger AE]]
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<ref group="xtra">PMID:15616594</ref><references group="xtra"/>
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[[Category: Heath R]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Kriwacki RW]]
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[[Category: Bjorkman, P J.]]
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[[Category: Lacy ER]]
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[[Category: Hamburger, A E.]]
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[[Category: Lewis WS]]
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[[Category: Heath, R.]]
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[[Category: Luo R]]
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[[Category: Kriwacki, R W.]]
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[[Category: Mann B]]
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[[Category: Lacy, E R.]]
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[[Category: Rowe A]]
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[[Category: Lewis, W S.]]
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[[Category: Sivakolundu S]]
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[[Category: Luo, R.]]
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[[Category: Stewart ML]]
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[[Category: Mann, B.]]
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[[Category: Tuomanen E]]
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[[Category: Rowe, A.]]
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[[Category: Sivakolundu, S.]]
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[[Category: Stewart, M L.]]
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[[Category: Tuomanen, E.]]
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[[Category: Adhesion]]
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[[Category: Cbpa]]
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[[Category: Invasion]]
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[[Category: Pathogenesis]]
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[[Category: Pigr]]
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[[Category: Polymeric immunoglobulin receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 09:58:57 2009''
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Current revision

Solution Structure of Choline Binding Protein A, Domain R2, the Major Adhesin of Streptococcus pneumoniae

PDB ID 1w9r

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