1x5a

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(New page: 200px<br /><applet load="1x5a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1x5a" /> '''The solution structure of the second fibrone...)
Current revision (13:59, 9 May 2024) (edit) (undo)
 
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[[Image:1x5a.gif|left|200px]]<br /><applet load="1x5a" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1x5a" />
 
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'''The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1'''<br />
 
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==About this Structure==
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==The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1==
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1X5A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Active as [http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1X5A OCA].
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<StructureSection load='1x5a' size='340' side='right'caption='[[1x5a]]' scene=''>
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[[Category: Mus musculus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1x5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5A FirstGlance]. <br>
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[[Category: Transferase]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Inoue, M.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5a OCA], [https://pdbe.org/1x5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5a RCSB], [https://www.ebi.ac.uk/pdbsum/1x5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5a ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5a TOPSAN]</span></td></tr>
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[[Category: Kigawa, T.]]
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</table>
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[[Category: Koshiba, S.]]
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== Function ==
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[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
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[https://www.uniprot.org/uniprot/EPHA1_MOUSE EPHA1_MOUSE] Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.<ref>PMID:18802966</ref>
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[[Category: Sasagawa, A.]]
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== Evolutionary Conservation ==
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[[Category: Tochio, N.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Yokoyama, S.]]
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Check<jmol>
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[[Category: esk]]
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<jmolCheckbox>
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[[Category: fibronectin type iii (fn3) domain]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x5/1x5a_consurf.spt"</scriptWhenChecked>
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[[Category: national project on protein structural and functional analyses]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: nppsfa]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: riken structural genomics/proteomics initiative]]
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</jmolCheckbox>
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[[Category: rsgi]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x5a ConSurf].
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[[Category: structural genomics]]
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<div style="clear:both"></div>
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[[Category: tyrosine-protein kinase receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 05:51:00 2007''
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==See Also==
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*[[Ephrin receptor 3D structures|Ephrin receptor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Inoue M]]
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[[Category: Kigawa T]]
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[[Category: Koshiba S]]
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[[Category: Sasagawa A]]
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[[Category: Tochio N]]
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[[Category: Yokoyama S]]

Current revision

The solution structure of the second fibronectin type III domain of mouse Ephrin type-A receptor 1

PDB ID 1x5a

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