1s4z

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{{Seed}}
 
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[[Image:1s4z.png|left|200px]]
 
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==HP1 chromo shadow domain in complex with PXVXL motif of CAF-1==
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The line below this paragraph, containing "STRUCTURE_1s4z", creates the "Structure Box" on the page.
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<StructureSection load='1s4z' size='340' side='right'caption='[[1s4z]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s4z]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S4Z FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s4z OCA], [https://pdbe.org/1s4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s4z RCSB], [https://www.ebi.ac.uk/pdbsum/1s4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s4z ProSAT]</span></td></tr>
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{{STRUCTURE_1s4z| PDB=1s4z | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CBX1_MOUSE CBX1_MOUSE] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s4z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s4z ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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HP1 family proteins are adaptor molecules, containing two related chromo domains that are required for chromatin packaging and gene silencing. Here we present the structure of the chromo shadow domain from mouse HP1beta bound to a peptide containing a consensus PXVXL motif found in many HP1 binding partners. The shadow domain exhibits a novel mode of peptide recognition, where the peptide binds across the dimer interface, sandwiched in a beta-sheet between strands from each monomer. The structure allows us to predict which other shadow domains bind similar PXVXL motif-containing peptides and provides a framework for predicting the sequence specificity of the others. We show that targeting of HP1beta to heterochromatin requires shadow domain interactions with PXVXL-containing proteins in addition to chromo domain recognition of Lys-9-methylated histone H3. Interestingly, it also appears to require the simultaneous recognition of two Lys-9-methylated histone H3 molecules. This finding implies a further complexity to the histone code for regulation of chromatin structure and suggests how binding of HP1 family proteins may lead to its condensation.
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===HP1 chromo shadow domain in complex with PXVXL motif of CAF-1===
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Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.,Thiru A, Nietlispach D, Mott HR, Okuwaki M, Lyon D, Nielsen PR, Hirshberg M, Verreault A, Murzina NV, Laue ED EMBO J. 2004 Feb 11;23(3):489-99. Epub 2004 Feb 5. PMID:14765118<ref>PMID:14765118</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14765118}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1s4z" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14765118 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14765118}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1S4Z is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S4Z OCA].
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==Reference==
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<ref group="xtra">PMID:14765118</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Hirshberg, M.]]
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[[Category: Hirshberg M]]
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[[Category: Laue, E D.]]
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[[Category: Laue ED]]
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[[Category: Lyon, D.]]
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[[Category: Lyon D]]
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[[Category: Mott, H R.]]
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[[Category: Mott HR]]
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[[Category: Murzina, N V.]]
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[[Category: Murzina NV]]
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[[Category: Nielsen, P R.]]
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[[Category: Nielsen PR]]
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[[Category: Nietlispach, D.]]
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[[Category: Nietlispach D]]
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[[Category: Okuwaki, M.]]
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[[Category: Okuwaki M]]
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[[Category: Thiru, A.]]
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[[Category: Thiru A]]
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[[Category: Verreault, A.]]
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[[Category: Verreault A]]
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[[Category: Gene regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:21:37 2009''
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Current revision

HP1 chromo shadow domain in complex with PXVXL motif of CAF-1

PDB ID 1s4z

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