3crd

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{{Seed}}
 
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[[Image:3crd.png|left|200px]]
 
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==NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_3crd", creates the "Structure Box" on the page.
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<StructureSection load='3crd' size='340' side='right'caption='[[3crd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3crd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CRD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3crd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3crd OCA], [https://pdbe.org/3crd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3crd RCSB], [https://www.ebi.ac.uk/pdbsum/3crd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3crd ProSAT]</span></td></tr>
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{{STRUCTURE_3crd| PDB=3crd | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN] Defects in CRADD are the cause of mental retardation autosomal recessive type 34 (MRT34) [MIM:[https://omim.org/entry/614499 614499]. A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRT34 is a non-syndromic form. Affected individuals have mildly delayed development and significantly impaired cognitive function, precluding independent living and self-care. Speech is rudimentary, but articulate; autism is not present.<ref>PMID:22279524</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CRADD_HUMAN CRADD_HUMAN] Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cr/3crd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3crd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Apoptosis requires recruitment of caspases by receptor-associated adaptors through homophilic interactions between the CARDs (caspase recruitment domains) of adaptor proteins and prodomains of caspases. We have solved the CARD structure of the RAIDD adaptor protein that recruits ICH-1/caspase-2. It consists of six tightly packed helices arranged in a topology homologous to the Fas death domain. The surface contains a basic and an acidic patch on opposite sides. This polarity is conserved in the ICH-1 CARD as indicated by homology modeling. Mutagenesis data suggest that these patches mediate CARD/CARD interaction between RAIDD and ICH-1. Subsequent modeling of the CARDs of Apaf-1 and caspase-9, as well as Ced-4 and Ced-3, showed that the basic/acidic surface polarity is highly conserved, suggesting a general mode for CARD/CARD interaction.
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===NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES===
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Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.,Chou JJ, Matsuo H, Duan H, Wagner G Cell. 1998 Jul 24;94(2):171-80. PMID:9695946<ref>PMID:9695946</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9695946}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3crd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9695946 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9695946}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3CRD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CRD OCA].
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==Reference==
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<ref group="xtra">PMID:9695946</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chou, J J.]]
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[[Category: Large Structures]]
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[[Category: Duan, H.]]
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[[Category: Chou JJ]]
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[[Category: Matsuo, H.]]
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[[Category: Duan H]]
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[[Category: Wagner, G.]]
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[[Category: Matsuo H]]
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[[Category: Apoptosis]]
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[[Category: Wagner G]]
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[[Category: Caspase recruitment domain]]
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[[Category: Homophilic interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:31:50 2009''
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Current revision

NMR STRUCTURE OF THE RAIDD CARD DOMAIN, 15 STRUCTURES

PDB ID 3crd

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