1mm0

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{{Seed}}
 
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[[Image:1mm0.png|left|200px]]
 
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==Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger==
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The line below this paragraph, containing "STRUCTURE_1mm0", creates the "Structure Box" on the page.
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<StructureSection load='1mm0' size='340' side='right'caption='[[1mm0]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1mm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudacanthotermes_spiniger Pseudacanthotermes spiniger]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MM0 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mm0 OCA], [https://pdbe.org/1mm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mm0 RCSB], [https://www.ebi.ac.uk/pdbsum/1mm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mm0 ProSAT]</span></td></tr>
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{{STRUCTURE_1mm0| PDB=1mm0 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TERN_PSEUS TERN_PSEUS] Weak activity against Gram-positive bacteria B.megaterium, S.pyogenes and M.luteus, strong activity against yeasts C.albicans, C.neoformans and S.cerevisiae and filamentous fungi F.oxysporum, F.culmorum, N.crassa and N.hematococca. Less active against filamentous fungus T.viride. Inactive against Gram-positive bacteria A.viridans and S.aureus, filamentous fungi A.fumigatus and B.bassiana and yeast C.glabrata.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mm/1mm0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mm0 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The solution structure of termicin from hemocytes of the termite Pseudacanthotermes spiniger was determined by proton two-dimensional nuclear magnetic resonance spectroscopy and molecular modeling techniques. Termicin is a cysteine-rich antifungal peptide also exhibiting a weak antibacterial activity. The global fold of termicin consists of an alpha-helical segment (Phe4-Gln14) and a two-stranded (Phe19-Asp25 and Gln28-Phe33) antiparallel beta-sheet forming a "cysteine stabilized alphabeta motif" (CSalphabeta) also found in antibacterial and antifungal defensins from insects and from plants. Interestingly, termicin shares more structural similarities with the antibacterial insect defensins and with MGD-1, a mussel defensin, than with the insect antifungal defensins such as drosomycin and heliomicin. These structural comparisons suggest that global fold alone does not explain the difference between antifungals and antibacterials. The antifungal properties of termicin may be related to its marked hydrophobicity and its amphipatic structure as compared to the antibacterial defensins. [SWISS-PROT accession number: Termicin (P82321); PDB accession number: 1MM0.]
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===Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger===
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Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger.,Da Silva P, Jouvensal L, Lamberty M, Bulet P, Caille A, Vovelle F Protein Sci. 2003 Mar;12(3):438-46. PMID:12592014<ref>PMID:12592014</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12592014}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1mm0" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12592014 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12592014}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1MM0 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Pseudacanthotermes_spiniger Pseudacanthotermes spiniger]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MM0 OCA].
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==Reference==
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<ref group="xtra">PMID:12592014</ref><references group="xtra"/>
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[[Category: Pseudacanthotermes spiniger]]
[[Category: Pseudacanthotermes spiniger]]
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[[Category: Bulet, P.]]
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[[Category: Bulet P]]
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[[Category: Caille, A.]]
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[[Category: Caille A]]
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[[Category: Jouvensal, L.]]
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[[Category: Da Silva P]]
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[[Category: Lamberty, M.]]
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[[Category: Jouvensal L]]
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[[Category: Silva, P Da.]]
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[[Category: Lamberty M]]
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[[Category: Vovelle, F.]]
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[[Category: Vovelle F]]
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[[Category: Antimicrobial peptide]]
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[[Category: Csab motif]]
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[[Category: Cytein-rich]]
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[[Category: Insect defensin]]
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[[Category: Nmr]]
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[[Category: Termite]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:37:28 2009''
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Current revision

Solution structure of termicin, an antimicrobial peptide from the termite Pseudacanthotermes spiniger

PDB ID 1mm0

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