1u5t

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{{Seed}}
 
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[[Image:1u5t.png|left|200px]]
 
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==Structure of the ESCRT-II endosomal trafficking complex==
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The line below this paragraph, containing "STRUCTURE_1u5t", creates the "Structure Box" on the page.
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<StructureSection load='1u5t' size='340' side='right'caption='[[1u5t]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u5t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U5T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u5t OCA], [https://pdbe.org/1u5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u5t RCSB], [https://www.ebi.ac.uk/pdbsum/1u5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u5t ProSAT]</span></td></tr>
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{{STRUCTURE_1u5t| PDB=1u5t | SCENE= }}
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</table>
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== Function ==
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===Structure of the ESCRT-II endosomal trafficking complex===
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[https://www.uniprot.org/uniprot/SNF8_YEAST SNF8_YEAST] Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15329733 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u5/1u5t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15329733}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u5t ConSurf].
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1U5T is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U5T OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:15329733</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Emr, S D.]]
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[[Category: Emr SD]]
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[[Category: Hierro, A.]]
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[[Category: Hierro A]]
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[[Category: Hurley, J H.]]
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[[Category: Hurley JH]]
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[[Category: Kim, J.]]
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[[Category: Kim J]]
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[[Category: Prag, G.]]
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[[Category: Prag G]]
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[[Category: Rusnak, A S.]]
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[[Category: Rusnak AS]]
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[[Category: Sun, J.]]
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[[Category: Sun J]]
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[[Category: Endosomal]]
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[[Category: Escrt]]
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[[Category: Protein complex]]
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[[Category: Trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:46:40 2009''
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Current revision

Structure of the ESCRT-II endosomal trafficking complex

PDB ID 1u5t

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OCA

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