1fmm

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{{Seed}}
 
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[[Image:1fmm.png|left|200px]]
 
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==SOLUTION STRUCTURE OF NFGF-1==
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The line below this paragraph, containing "STRUCTURE_1fmm", creates the "Structure Box" on the page.
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<StructureSection load='1fmm' size='340' side='right'caption='[[1fmm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fmm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Notophthalmus_viridescens Notophthalmus viridescens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fmm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fmm OCA], [https://pdbe.org/1fmm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fmm RCSB], [https://www.ebi.ac.uk/pdbsum/1fmm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fmm ProSAT]</span></td></tr>
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{{STRUCTURE_1fmm| PDB=1fmm | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FGF1_NOTVI FGF1_NOTVI] Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fm/1fmm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fmm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional solution structure of an acidic fibroblast growth factor (nFGF-1) from the newt (Notophthalmus viridescens) is determined using multidimensional NMR techniques. Complete assignment of all the atoms ((1)H, (15)N, and (13)C) has been achieved using a variety of triple resonance experiments. 50 structures were calculated using hybrid distance geometry-dynamical simulated annealing technique with a total of 1359 constraints. The atomic root mean square distribution for the backbone atoms in the structured region is 0.60 A. The secondary structural elements include 12 beta-strands arranged antiparallely into a beta-barrel structure. The protein (nFGF-1) exists in a monomeric state upon binding to the ligand, sucrose octa sulfate (SOS), in a stoichiometric ratio of 1:1. The SOS binding site consists of a dense cluster of positively charged residues located at the C-terminal end of the molecule. The conformational stabilities of nFGF-1 and its structural and functional homologue from the human source (hFGF-1) are drastically different. The differential stabilities of nFGF-1 and hFGF-1 are attributed to the differences in the number of hydrogen bonds and the presence of solvent inaccessible cavities in the two proteins.
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===SOLUTION STRUCTURE OF NFGF-1===
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Structure and stability of an acidic fibroblast growth factor from Notophthalmus viridescens.,Arunkumar AI, Srisailam S, Kumar TK, Kathir KM, Chi YH, Wang HM, Chang GG, Chiu I, Yu C J Biol Chem. 2002 Nov 29;277(48):46424-32. Epub 2002 Aug 29. PMID:12205097<ref>PMID:12205097</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1fmm" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12205097}}, adds the Publication Abstract to the page
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*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12205097 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12205097}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1FMM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Notophthalmus_viridescens Notophthalmus viridescens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMM OCA].
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==Reference==
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<ref group="xtra">PMID:12205097</ref><references group="xtra"/>
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[[Category: Notophthalmus viridescens]]
[[Category: Notophthalmus viridescens]]
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[[Category: Arunkumar, A I.]]
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[[Category: Arunkumar AI]]
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[[Category: Chiu, I M.]]
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[[Category: Chiu IM]]
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[[Category: Kumar, T K.S.]]
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[[Category: Kumar TKS]]
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[[Category: Srisailam, S.]]
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[[Category: Srisailam S]]
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[[Category: Yu, C.]]
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[[Category: Yu C]]
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[[Category: Growth factor]]
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[[Category: Mitogen]]
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[[Category: Triple resonance]]
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[[Category: Wound healing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 10:50:56 2009''
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Current revision

SOLUTION STRUCTURE OF NFGF-1

PDB ID 1fmm

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OCA

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