1l0q

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{{Seed}}
 
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[[Image:1l0q.png|left|200px]]
 
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==Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein==
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The line below this paragraph, containing "STRUCTURE_1l0q", creates the "Structure Box" on the page.
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<StructureSection load='1l0q' size='340' side='right'caption='[[1l0q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l0q]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_mazei_S-6 Methanosarcina mazei S-6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L0Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
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{{STRUCTURE_1l0q| PDB=1l0q | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l0q OCA], [https://pdbe.org/1l0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l0q RCSB], [https://www.ebi.ac.uk/pdbsum/1l0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l0q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q50245_METMZ Q50245_METMZ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/1l0q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l0q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The surface layer of archaeobacteria protects cells from extreme environments and, in Methanosarcina, may regulate cell adhesion. We identify three domain types that account for the complete architecture of numerous Methanosarcina surface layer proteins (SLPs). We solve the crystal structure for two of these domains, which correspond to the two N-terminal domains of an M. mazei SLP. One domain displays a unique, highly symmetrical, seven-bladed beta propeller fold, and the other belongs to the polycystic kidney disease (PKD) superfamily fold. The third domain is predicted to adopt a beta helix fold. These domains have homologs in metazoan cell surface proteins, suggesting remarkable relationships between domains in archaeal SLPs and metazoan cell surface proteins.
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===Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein===
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Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.,Jing H, Takagi J, Liu JH, Lindgren S, Zhang RG, Joachimiak A, Wang JH, Springer TA Structure. 2002 Oct;10(10):1453-64. PMID:12377130<ref>PMID:12377130</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12377130}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1l0q" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12377130 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12377130}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1L0Q is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Archaea Archaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L0Q OCA].
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[[Category: Methanosarcina mazei S-6]]
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[[Category: Jing H]]
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==Reference==
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[[Category: Joachimiak A]]
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<ref group="xtra">PMID:12377130</ref><references group="xtra"/>
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[[Category: Lindgren S]]
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[[Category: Archaea]]
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[[Category: Liu J-H]]
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[[Category: Jing, H.]]
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[[Category: Springer TA]]
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[[Category: Joachimiak, A.]]
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[[Category: Takagi J]]
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[[Category: Lindgren, S.]]
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[[Category: Wang J-H]]
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[[Category: Liu, J H.]]
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[[Category: Zhang R-G]]
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[[Category: Springer, T A.]]
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[[Category: Takagi, J.]]
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[[Category: Wang, J H.]]
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[[Category: Zhang, R G.]]
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[[Category: 7-bladed beta-propeller]]
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[[Category: Pkd superfamily]]
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[[Category: S-layer]]
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[[Category: Slp]]
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[[Category: Surface layer protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:16:25 2009''
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Current revision

Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein

PDB ID 1l0q

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