1l9y

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{{Seed}}
 
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[[Image:1l9y.png|left|200px]]
 
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==FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii==
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The line below this paragraph, containing "STRUCTURE_1l9y", creates the "Structure Box" on the page.
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<StructureSection load='1l9y' size='340' side='right'caption='[[1l9y]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1l9y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Fluoribacter_gormanii Fluoribacter gormanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L9Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1l9y| PDB=1l9y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l9y OCA], [https://pdbe.org/1l9y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l9y RCSB], [https://www.ebi.ac.uk/pdbsum/1l9y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l9y ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9K578_9GAMM Q9K578_9GAMM]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l9/1l9y_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l9y ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The beta-lactamases are involved in bacterial resistance to penicillin and related compounds. Members of the metallo-enzyme class are now found in many pathogenic bacteria and are thus becoming of major clinical importance. The structures of the Zn-beta-lactamase from Fluoribacter gormanii (FEZ-1) in the native and in the complex form are reported here. FEZ-1 is a monomeric enzyme, which possesses two zinc-binding sites. These structures are discussed in comparison with those of the tetrameric L1 enzyme produced by Stenotrophomonas maltophilia. From this analysis, amino acids involved in the oligomerization of L1 are clearly identified. Despite the similarity in fold, the active site of FEZ-1 was found to be significantly different. Two residues, which were previously implicated in function, are not present in L1 or in FEZ-1. The broad-spectrum substrate profile of Zn-beta-lactamases arises from the rather wide active-site cleft, where various beta-lactam compounds can be accommodated.
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===FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii===
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Three-dimensional structure of FEZ-1, a monomeric subclass B3 metallo-beta-lactamase from Fluoribacter gormanii, in native form and in complex with D-captopril.,Garcia-Saez I, Mercuri PS, Papamicael C, Kahn R, Frere JM, Galleni M, Rossolini GM, Dideberg O J Mol Biol. 2003 Jan 24;325(4):651-60. PMID:12507470<ref>PMID:12507470</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1l9y" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_12507470}}, adds the Publication Abstract to the page
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12507470 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12507470}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1L9Y is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Fluoribacter_gormanii Fluoribacter gormanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L9Y OCA].
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==Reference==
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<ref group="xtra">PMID:12507470</ref><references group="xtra"/>
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[[Category: Beta-lactamase]]
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[[Category: Fluoribacter gormanii]]
[[Category: Fluoribacter gormanii]]
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[[Category: Dideberg, O.]]
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[[Category: Large Structures]]
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[[Category: Galleni, M.]]
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[[Category: Dideberg O]]
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[[Category: Garcia-Saez, I.]]
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[[Category: Galleni M]]
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[[Category: Mercuri, P S.]]
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[[Category: Garcia-Saez I]]
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[[Category: Monomer with alpha-beta/beta-alpha fold]]
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[[Category: Mercuri PS]]
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[[Category: Two monomers per assymmetric unit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:32:50 2009''
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Current revision

FEZ-1-Y228A, A Mutant of the Metallo-beta-lactamase from Legionella gormanii

PDB ID 1l9y

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