1xe7

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(New page: 200px<br /><applet load="1xe7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xe7, resolution 1.75&Aring;" /> '''Crystal structure of...)
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[[Image:1xe7.gif|left|200px]]<br /><applet load="1xe7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xe7, resolution 1.75&Aring;" />
 
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'''Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold'''<br />
 
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==Overview==
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==Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold==
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We determined the three-dimensional crystal structure of the protein, YML079wp, encoded by a hypothetical open reading frame from Saccharomyces, cerevisiae to a resolution of 1.75 A. The protein has no close homologs, and its molecular and cellular functions are unknown. The structure of the, protein is a jelly-roll fold consisting of ten beta-strands organized in, two parallel packed beta-sheets. The protein has strong structural, resemblance to the plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) but also to some plant and bacterial, enzymes (epimerase, germin). The protein forms homodimers in the crystal, confirming measurements of its molecular mass in solution. Two monomers, have their beta-sheet packed together to form the dimer. The presence of a, hydrophobic ligand in a well conserved pocket inside the barrel and local, sequence similarity with bacterial epimerases may suggest a biochemical, function for this protein.
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<StructureSection load='1xe7' size='340' side='right'caption='[[1xe7]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1xe7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XE7 FirstGlance]. <br>
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1XE7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with GUN, EDO and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XE7 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe7 OCA], [https://pdbe.org/1xe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xe7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xe7 ProSAT]</span></td></tr>
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Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly-roll fold., Zhou CZ, Meyer P, Quevillon-Cheruel S, De La Sierra-Gallay IL, Collinet B, Graille M, Blondeau K, Francois JM, Leulliot N, Sorel I, Poupon A, Janin J, Van Tilbeurgh H, Protein Sci. 2005 Jan;14(1):209-15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15608122 15608122]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YMH9_YEAST YMH9_YEAST]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xe7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xe7 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Collinet B]]
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[[Category: Collinet, B.]]
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[[Category: Graille M]]
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[[Category: Graille, M.]]
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[[Category: Janin J]]
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[[Category: Janin, J.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Li de La Sierra-Gallay I]]
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[[Category: Meyer, P.]]
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[[Category: Meyer P]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Sierra-Gallay, I.Li.de.La.]]
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[[Category: Sorel I]]
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[[Category: Sorel, I.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H.Van.]]
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[[Category: Zhou C-Z]]
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[[Category: Zhou, C.Z.]]
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[[Category: ACY]]
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[[Category: EDO]]
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[[Category: GUN]]
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[[Category: cupin superfamily]]
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[[Category: jelly roll motif]]
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[[Category: s. cerevisiae]]
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[[Category: structural genomics]]
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[[Category: yml079wp]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:01:08 2007''
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Current revision

Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold

PDB ID 1xe7

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