1q3e

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{{Seed}}
 
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[[Image:1q3e.png|left|200px]]
 
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==HCN2J 443-645 in the presence of cGMP==
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The line below this paragraph, containing "STRUCTURE_1q3e", creates the "Structure Box" on the page.
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<StructureSection load='1q3e' size='340' side='right'caption='[[1q3e]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1q3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Q3E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
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{{STRUCTURE_1q3e| PDB=1q3e | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3e OCA], [https://pdbe.org/1q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1q3e RCSB], [https://www.ebi.ac.uk/pdbsum/1q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1q3e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HCN2_MOUSE HCN2_MOUSE] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages.<ref>PMID:11741901</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/1q3e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1q3e ConSurf].
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<div style="clear:both"></div>
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===HCN2J 443-645 in the presence of cGMP===
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12968185}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12968185 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12968185}}
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==About this Structure==
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1Q3E is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q3E OCA].
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==Reference==
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<ref group="xtra">PMID:12968185</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Black, K D.]]
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[[Category: Black KD]]
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[[Category: Gouaux, J E.]]
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[[Category: Gouaux JE]]
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[[Category: Olivier, N B.]]
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[[Category: Olivier NB]]
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[[Category: Olson, R.]]
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[[Category: Olson R]]
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[[Category: Young, E C.]]
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[[Category: Young EC]]
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[[Category: Zagotta, W N.]]
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[[Category: Zagotta WN]]
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[[Category: C-linker]]
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[[Category: Cap]]
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[[Category: Cgmp]]
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[[Category: Channel]]
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[[Category: Cnbd]]
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[[Category: Cyclic nucleotide]]
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[[Category: Hcn]]
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[[Category: Ion channel]]
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[[Category: Ligand]]
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[[Category: Pacemaker]]
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[[Category: Pka]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:47:09 2009''
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Current revision

HCN2J 443-645 in the presence of cGMP

PDB ID 1q3e

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