1xeq

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(New page: 200px<br /><applet load="1xeq" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xeq, resolution 2.10&Aring;" /> '''Crystal tructure of ...)
Current revision (08:50, 14 February 2024) (edit) (undo)
 
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[[Image:1xeq.gif|left|200px]]<br /><applet load="1xeq" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xeq, resolution 2.10&Aring;" />
 
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'''Crystal tructure of RNA binding domain of influenza B virus non-structural protein'''<br />
 
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==About this Structure==
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==Crystal tructure of RNA binding domain of influenza B virus non-structural protein==
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1XEQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus] with BR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA].
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<StructureSection load='1xeq' size='340' side='right'caption='[[1xeq]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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[[Category: Influenza b virus]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1xeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Lee/1940) Influenza B virus (B/Lee/1940)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XEQ FirstGlance]. <br>
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[[Category: Khan, J.A.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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[[Category: Krug, R.M.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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[[Category: Montelione, G.T.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xeq OCA], [https://pdbe.org/1xeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xeq RCSB], [https://www.ebi.ac.uk/pdbsum/1xeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xeq ProSAT], [https://www.topsan.org/Proteins/NESGC/1xeq TOPSAN]</span></td></tr>
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[[Category: NESG, Northeast.Structural.Genomics.Consortium.]]
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</table>
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[[Category: Tong, L.]]
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== Function ==
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[[Category: Yin, C.]]
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[https://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
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[[Category: BR]]
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[[Category: influenza b virus]]
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[[Category: nesg]]
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[[Category: non-structural protein]]
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[[Category: northeast structural genomics consortium]]
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[[Category: ns1b]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: rna binding domain]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:01:44 2007''
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==See Also==
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*[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Khan JA]]
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[[Category: Krug RM]]
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[[Category: Montelione GT]]
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[[Category: Tong L]]
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[[Category: Yin C]]

Current revision

Crystal tructure of RNA binding domain of influenza B virus non-structural protein

PDB ID 1xeq

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