1wpa

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:33, 13 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1wpa.png|left|200px]]
 
-
<!--
+
==1.5 Angstrom crystal structure of human occludin fragment 413-522==
-
The line below this paragraph, containing "STRUCTURE_1wpa", creates the "Structure Box" on the page.
+
<StructureSection load='1wpa' size='340' side='right'caption='[[1wpa]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1wpa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WPA FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wpa OCA], [https://pdbe.org/1wpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wpa RCSB], [https://www.ebi.ac.uk/pdbsum/1wpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wpa ProSAT]</span></td></tr>
-
{{STRUCTURE_1wpa| PDB=1wpa | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===1.5 Angstrom crystal structure of human occludin fragment 413-522===
+
[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] Defects in OCLN are the cause of band-like calcification with simplified gyration and polymicrogyria (BLCPMG) [MIM:[https://omim.org/entry/251290 251290]; also known as pseudo-TORCH syndrome. BLCPMG is a neurologic disorder with characteristic clinical and neuroradiologic features that mimic intrauterine TORCH infection in the absence of evidence of infection. Affected individuals have congenital microcephaly, intracranial calcifications, and severe developmental delay.<ref>PMID:20727516</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/OCLN_HUMAN OCLN_HUMAN] May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctions.<ref>PMID:19114660</ref>
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_16081103}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16081103 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_16081103}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/1wpa_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
1WPA is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WPA OCA].
+
</jmolCheckbox>
-
 
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wpa ConSurf].
-
==Reference==
+
<div style="clear:both"></div>
-
<ref group="xtra">PMID:16081103</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Anderson, J M.]]
+
[[Category: Large Structures]]
-
[[Category: Fanning, A S.]]
+
[[Category: Anderson JM]]
-
[[Category: Lavie, A.]]
+
[[Category: Fanning AS]]
-
[[Category: Li, Y.]]
+
[[Category: Lavie A]]
-
[[Category: Coiled-coil]]
+
[[Category: Li Y]]
-
[[Category: Occludin]]
+
-
[[Category: Transmembrane protein]]
+
-
[[Category: Zo-1 binding]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 11:56:38 2009''
+

Current revision

1.5 Angstrom crystal structure of human occludin fragment 413-522

PDB ID 1wpa

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1wpa"
Personal tools