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1lqq
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1lqq.png|left|200px]] | ||
| - | + | ==ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES== | |
| - | + | <StructureSection load='1lqq' size='340' side='right'caption='[[1lqq]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1lqq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LQQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lqq OCA], [https://pdbe.org/1lqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lqq RCSB], [https://www.ebi.ac.uk/pdbsum/1lqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lqq ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SCX3_LEIQU SCX3_LEIQU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This contractive toxin is highly toxic both to mammals and insects. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lq/1lqq_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lqq ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Hemolysin 3D structures|Hemolysin 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
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[[Category: Leiurus quinquestriatus quinquestriatus]] | [[Category: Leiurus quinquestriatus quinquestriatus]] | ||
| - | [[Category: Landon | + | [[Category: Landon C]] |
| - | [[Category: Ptak | + | [[Category: Ptak M]] |
| - | [[Category: Sodano | + | [[Category: Sodano P]] |
| - | [[Category: Vovelle | + | [[Category: Vovelle F]] |
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Current revision
ANTI-MAMMAL AND ANTI-INSECT LQQIII SCORPION TOXIN, NMR, 15 STRUCTURES
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