2ofq

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{{Seed}}
 
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[[Image:2ofq.png|left|200px]]
 
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==NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system==
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The line below this paragraph, containing "STRUCTURE_2ofq", creates the "Structure Box" on the page.
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<StructureSection load='2ofq' size='340' side='right'caption='[[2ofq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ofq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/IncN_plasmid_R46 IncN plasmid R46]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OFQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ofq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ofq OCA], [https://pdbe.org/2ofq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ofq RCSB], [https://www.ebi.ac.uk/pdbsum/2ofq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ofq ProSAT]</span></td></tr>
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{{STRUCTURE_2ofq| PDB=2ofq | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q79SE3_SALTM Q79SE3_SALTM]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/of/2ofq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ofq ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Type IV secretion (T4S) systems translocate DNA and protein effectors through the double membrane of Gram-negative bacteria. The paradigmatic T4S system in Agrobacterium tumefaciens is assembled from 11 VirB subunits and VirD4. Two subunits, VirB9 and VirB7, form an important stabilizing complex in the outer membrane. We describe here the NMR structure of a complex between the C-terminal domain of the VirB9 homolog TraO (TraO(CT)), bound to VirB7-like TraN from plasmid pKM101. TraO(CT) forms a beta-sandwich around which TraN winds. Structure-based mutations in VirB7 and VirB9 of A. tumefaciens show that the heterodimer interface is conserved. Opposite this interface, the TraO structure shows a protruding three-stranded beta-appendage, and here, we supply evidence that the corresponding region of VirB9 of A. tumefaciens inserts in the membrane and protrudes extracellularly. This complex structure elucidates the molecular basis for the interaction between two essential components of a T4S system.
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===NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system===
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NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system.,Bayliss R, Harris R, Coutte L, Monier A, Fronzes R, Christie PJ, Driscoll PC, Waksman G Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1673-8. Epub 2007 Jan 23. PMID:17244707<ref>PMID:17244707</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17244707}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ofq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17244707 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17244707}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: IncN plasmid R46]]
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2OFQ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Incn_plasmid_r46 Incn plasmid r46]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OFQ OCA].
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[[Category: Large Structures]]
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[[Category: Bayliss R]]
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==Reference==
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[[Category: Driscoll PC]]
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<ref group="xtra">PMID:17244707</ref><references group="xtra"/>
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[[Category: Harris R]]
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[[Category: Incn plasmid r46]]
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[[Category: Waksman G]]
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[[Category: Bayliss, R.]]
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[[Category: Driscoll, P C.]]
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[[Category: Harris, R.]]
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[[Category: Waksman, G.]]
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[[Category: Pkm101]]
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[[Category: Tran]]
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[[Category: Trao]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:11:28 2009''
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Current revision

NMR Solution Structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

PDB ID 2ofq

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