1drs

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{{Seed}}
 
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[[Image:1drs.png|left|200px]]
 
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==THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN==
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The line below this paragraph, containing "STRUCTURE_1drs", creates the "Structure Box" on the page.
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<StructureSection load='1drs' size='340' side='right'caption='[[1drs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1drs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DRS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 39 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1drs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1drs OCA], [https://pdbe.org/1drs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1drs RCSB], [https://www.ebi.ac.uk/pdbsum/1drs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1drs ProSAT]</span></td></tr>
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{{STRUCTURE_1drs| PDB=1drs | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SPM_DENJA 3SPM_DENJA] Inhibits ADP-induced platelet aggregation and inhibits the binding of purified platelet fibrinogen receptor alpha-IIb/beta-3 (ITGA2B/ITGB3) to immobilized fibrinogen (PubMed:1591238). Has also been described to inhibit cell adhesion to fibrinogen, fibronectin, laminin and collagen (PubMed:11336631, PubMed:16798616).<ref>PMID:11336631</ref> <ref>PMID:1591238</ref> <ref>PMID:16798616</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dr/1drs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1drs ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dendroaspin is a short chain neurotoxin homologue from the venom of Elapidae snakes, which lacks neurotoxicity. Unlike neurotoxins, it contains an Arg-Gly-Asp-(RGD)-motif and functions as an inhibitor of platelet aggregation and platelet adhesion with comparable potency to the disintegrins from the venoms of Viperidae. We have determined the structure of dendroaspin in solution using NMR spectroscopy. The structure contains a core similar to that of short chain neurotoxins, but with a novel arrangement of loops and a solvent-exposed RGD-motif. Dendroaspin is thus an integrin antagonist with a well defined fold different from that of the disintegrins, based on the neurotoxin scaffold.
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===THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN===
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Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.,Sutcliffe MJ, Jaseja M, Hyde EI, Lu X, Williams JA Nat Struct Biol. 1994 Nov;1(11):802-7. PMID:7634091<ref>PMID:7634091</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_7634091}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1drs" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 7634091 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_7634091}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1DRS is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_jamesoni_kaimosae Dendroaspis jamesoni kaimosae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DRS OCA].
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==Reference==
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<ref group="xtra">PMID:7634091</ref><references group="xtra"/>
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[[Category: Dendroaspis jamesoni kaimosae]]
[[Category: Dendroaspis jamesoni kaimosae]]
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[[Category: Hyde, E I.]]
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[[Category: Large Structures]]
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[[Category: Jaseja, M.]]
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[[Category: Hyde EI]]
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[[Category: Lu, X.]]
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[[Category: Jaseja M]]
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[[Category: Sutcliffe, M J.]]
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[[Category: Lu X]]
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[[Category: Williams, J A.]]
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[[Category: Sutcliffe MJ]]
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[[Category: Cell adhesion protein]]
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[[Category: Williams JA]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:15:34 2009''
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Current revision

THREE-DIMENSIONAL STRUCTURE OF THE RGD-CONTAINING NEUROTOXIN HOMOLOGUE, DENDROASPIN

PDB ID 1drs

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