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1jzb
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1jzb.png|left|200px]] | ||
| - | + | ==Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing== | |
| - | + | <StructureSection load='1jzb' size='340' side='right'caption='[[1jzb]], [[Resolution|resolution]] 2.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1jzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_sculpturatus Centruroides sculpturatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzb OCA], [https://pdbe.org/1jzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzb RCSB], [https://www.ebi.ac.uk/pdbsum/1jzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzb ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/SCX2_CENSC SCX2_CENSC] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more that 100 mg/kg).<ref>PMID:4460885</ref> | |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | < | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzb_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | + | </jmolCheckbox> | |
| - | == | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jzb ConSurf]. |
| - | + | <div style="clear:both"></div> | |
| - | + | == References == | |
| - | == | + | <references/> |
| - | < | + | __TOC__ |
| + | </StructureSection> | ||
[[Category: Centruroides sculpturatus]] | [[Category: Centruroides sculpturatus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Cook WJ]] |
| - | [[Category: | + | [[Category: Ealick SE]] |
| - | [[Category: | + | [[Category: Watt DD]] |
| - | [[Category: | + | [[Category: Zell A]] |
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Current revision
Crystal Structure of Variant 2 Scorpion Toxin from Centruroides sculpturatus Ewing
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