1vdd

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{{Seed}}
 
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[[Image:1vdd.png|left|200px]]
 
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==Crystal structure of recombinational repair protein RecR==
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The line below this paragraph, containing "STRUCTURE_1vdd", creates the "Structure Box" on the page.
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<StructureSection load='1vdd' size='340' side='right'caption='[[1vdd]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1vdd]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VDD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1vdd| PDB=1vdd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vdd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vdd OCA], [https://pdbe.org/1vdd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vdd RCSB], [https://www.ebi.ac.uk/pdbsum/1vdd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vdd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RECR_DEIRA RECR_DEIRA] May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/1vdd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vdd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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RecR, together with RecF and RecO, facilitates RecA loading in the RecF pathway of homologous recombinational DNA repair in procaryotes. The human Rad52 protein is a functional counterpart of RecFOR. We present here the crystal structure of RecR from Deinococcus radiodurans (DR RecR). A monomer of DR RecR has a two-domain structure: the N-terminal domain with a helix-hairpin-helix (HhH) motif and the C-terminal domain with a Cys4 zinc-finger motif, a Toprim domain and a Walker B motif. Four such monomers form a ring-shaped tetramer of 222 symmetry with a central hole of 30-35 angstroms diameter. In the crystal, two tetramers are concatenated, implying that the RecR tetramer is capable of opening and closing. We also show that DR RecR binds to both dsDNA and ssDNA, and that its HhH motif is essential for DNA binding.
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===Crystal structure of recombinational repair protein RecR===
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Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.,Lee BI, Kim KH, Park SJ, Eom SH, Song HK, Suh SW EMBO J. 2004 May 19;23(10):2029-38. Epub 2004 Apr 29. PMID:15116069<ref>PMID:15116069</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15116069}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1vdd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15116069 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15116069}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1VDD is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VDD OCA].
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==Reference==
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<ref group="xtra">PMID:15116069</ref><references group="xtra"/>
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[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Kim, K H.]]
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[[Category: Large Structures]]
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[[Category: Lee, B I.]]
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[[Category: Kim KH]]
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[[Category: Suh, S W.]]
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[[Category: Lee BI]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Suh SW]]
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[[Category: Toprim]]
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[[Category: Walker b atp binding motif]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:26:44 2009''
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Current revision

Crystal structure of recombinational repair protein RecR

PDB ID 1vdd

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