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1wrp
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:1wrp.png|left|200px]] | ||
| - | + | ==FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR== | |
| - | + | <StructureSection load='1wrp' size='340' side='right'caption='[[1wrp]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1wrp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WRP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WRP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wrp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wrp OCA], [https://pdbe.org/1wrp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wrp RCSB], [https://www.ebi.ac.uk/pdbsum/1wrp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wrp ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/TRPR_ECOLI TRPR_ECOLI] This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. | |
| - | + | == Evolutionary Conservation == | |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wrp_consurf.spt"</scriptWhenChecked> | |
| - | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |
| - | + | <text>to colour the structure by Evolutionary Conservation</text> | |
| - | == | + | </jmolCheckbox> |
| - | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wrp ConSurf]. | |
| - | + | <div style="clear:both"></div> | |
| - | == | + | __TOC__ |
| - | < | + | </StructureSection> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Joachimiak | + | [[Category: Large Structures]] |
| - | [[Category: Lawson | + | [[Category: Joachimiak A]] |
| - | [[Category: Otwinowski | + | [[Category: Lawson CL]] |
| - | [[Category: Schewitz | + | [[Category: Otwinowski Z]] |
| - | [[Category: Sigler | + | [[Category: Schewitz RW]] |
| - | + | [[Category: Sigler PB]] | |
| - | + | ||
| - | + | ||
Current revision
FLEXIBILITY OF THE DNA-BINDING DOMAINS OF TRP REPRESSOR
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