1k1s

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{{Seed}}
 
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[[Image:1k1s.png|left|200px]]
 
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==Crystal Structure of DinB from Sulfolobus solfataricus==
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The line below this paragraph, containing "STRUCTURE_1k1s", creates the "Structure Box" on the page.
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<StructureSection load='1k1s' size='340' side='right'caption='[[1k1s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1k1s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K1S FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k1s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1s OCA], [https://pdbe.org/1k1s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k1s RCSB], [https://www.ebi.ac.uk/pdbsum/1k1s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k1s ProSAT]</span></td></tr>
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{{STRUCTURE_1k1s| PDB=1k1s | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPO4_SACSO DPO4_SACSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k1/1k1s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k1s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A new group of error-prone DNA polymerases overcomes the blockage posed to normal DNA replication by damaged template bases, suggesting an active site with a loose, flexible pocket that accommodates aberrant DNA structures. We have determined a 2.8 A resolution crystal structure of the Sulfolobus solfataricus Dbh protein, a DNA translesion polymerase closely related to Escherichia coli DNA polymerase IV and human polymerase kappa. A high error rate is observed for the Dbh polymerase in a range of 10(-2)-10(-3) for all 12 base substitution mispairs. The crystal structure of Dbh reveals an overall architecture resembling other DNA polymerases but has unique features that are likely to contribute to error-prone synthesis, including -1 frameshifting mutations.
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===Crystal Structure of DinB from Sulfolobus solfataricus===
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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.,Silvian LF, Toth EA, Pham P, Goodman MF, Ellenberger T Nat Struct Biol. 2001 Nov;8(11):984-9. PMID:11685247<ref>PMID:11685247</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11685247}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1k1s" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11685247 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11685247}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1K1S is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1S OCA].
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[[Category: Saccharolobus solfataricus]]
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[[Category: Ellenberger T]]
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==Reference==
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[[Category: Goodman MF]]
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<ref group="xtra">PMID:11685247</ref><references group="xtra"/>
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[[Category: Pham P]]
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[[Category: Sulfolobus solfataricus]]
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[[Category: Silvian LF]]
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[[Category: Ellenberger, T.]]
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[[Category: Toth EA]]
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[[Category: Goodman, M F.]]
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[[Category: Pham, P.]]
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[[Category: Silvian, L F.]]
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[[Category: Toth, E A.]]
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[[Category: 4-stranded antiparallel b-sheet]]
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[[Category: Mixed a/b structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:39:05 2009''
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Current revision

Crystal Structure of DinB from Sulfolobus solfataricus

PDB ID 1k1s

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