1jsm

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{{Seed}}
 
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[[Image:1jsm.png|left|200px]]
 
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==STRUCTURE OF H5 AVIAN HAEMAGGLUTININ==
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The line below this paragraph, containing "STRUCTURE_1jsm", creates the "Structure Box" on the page.
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<StructureSection load='1jsm' size='340' side='right'caption='[[1jsm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1jsm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus Influenza A virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JSM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1jsm| PDB=1jsm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jsm OCA], [https://pdbe.org/1jsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jsm RCSB], [https://www.ebi.ac.uk/pdbsum/1jsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jsm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A5Z226_I97A2 A5Z226_I97A2] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS013828_004_327643]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/1jsm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jsm ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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There are 15 subtypes of influenza A virus (H1-H15), all of which are found in avian species. Three caused pandemics in the last century: H1 in 1918 (and 1977), H2 in 1957 and H3 in 1968. In 1997, an H5 avian virus and in 1999 an H9 virus caused outbreaks of respiratory disease in Hong Kong. We have determined the three-dimensional structures of the haemagglutinins (HAs) from H5 avian and H9 swine viruses closely related to the viruses isolated from humans in Hong Kong. We have compared them with known structures of the H3 HA from the virus that caused the 1968 H3 pandemic and of the HA--esterase--fusion (HEF) glycoprotein from an influenza C virus. Structure and sequence comparisons suggest that HA subtypes may have originated by diversification of properties that affected the metastability of HAs required for their membrane fusion activities in viral infection.
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===STRUCTURE OF H5 AVIAN HAEMAGGLUTININ===
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H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes.,Ha Y, Stevens DJ, Skehel JJ, Wiley DC EMBO J. 2002 Mar 1;21(5):865-75. PMID:11867515<ref>PMID:11867515</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1jsm" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_11867515}}, adds the Publication Abstract to the page
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*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 11867515 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11867515}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Influenza A virus]]
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1JSM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JSM OCA].
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[[Category: Large Structures]]
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[[Category: Ha Y]]
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==Reference==
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[[Category: Skehel JJ]]
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<ref group="xtra">PMID:11867515</ref><references group="xtra"/>
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[[Category: Stevens DJ]]
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[[Category: Influenza a virus]]
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[[Category: Wiley DC]]
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[[Category: Ha, Y.]]
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[[Category: Skehel, J J.]]
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[[Category: Stevens, D J.]]
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[[Category: Wiley, D C.]]
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[[Category: Fusion protein]]
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[[Category: Influenza]]
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[[Category: Receptor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:49:40 2009''
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Current revision

STRUCTURE OF H5 AVIAN HAEMAGGLUTININ

PDB ID 1jsm

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