2fg5

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{{Seed}}
 
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[[Image:2fg5.png|left|200px]]
 
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==Crystal structure of human RAB31 in complex with a GTP analogue==
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The line below this paragraph, containing "STRUCTURE_2fg5", creates the "Structure Box" on the page.
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<StructureSection load='2fg5' size='340' side='right'caption='[[2fg5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fg5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FG5 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_2fg5| PDB=2fg5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fg5 OCA], [https://pdbe.org/2fg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fg5 RCSB], [https://www.ebi.ac.uk/pdbsum/2fg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fg5 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB31_HUMAN RAB31_HUMAN] The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.<ref>PMID:17678623</ref> <ref>PMID:17189207</ref> <ref>PMID:19725050</ref> <ref>PMID:21586568</ref> <ref>PMID:21255211</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fg/2fg5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fg5 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human RAB31 in complex with a GTP analogue===
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2FG5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FG5 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bochkarev, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Bochkarev A]]
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[[Category: Ismail, S.]]
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[[Category: Edwards A]]
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[[Category: Park, H.]]
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[[Category: Ismail S]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Park H]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Tempel, W.]]
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[[Category: Tempel W]]
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[[Category: Wang, J.]]
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[[Category: Wang J]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: G-protein]]
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[[Category: Gtp analogue]]
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[[Category: Rab]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:50:07 2009''
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Current revision

Crystal structure of human RAB31 in complex with a GTP analogue

PDB ID 2fg5

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