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1lf7

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{{Seed}}
 
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[[Image:1lf7.png|left|200px]]
 
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<!--
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==Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution==
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The line below this paragraph, containing "STRUCTURE_1lf7", creates the "Structure Box" on the page.
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<StructureSection load='1lf7' size='340' side='right'caption='[[1lf7]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1lf7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LF7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LF7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
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{{STRUCTURE_1lf7| PDB=1lf7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lf7 OCA], [https://pdbe.org/1lf7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lf7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lf7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lf7 ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution===
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== Function ==
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[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12033936}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12033936 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lf7_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12033936}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1LF7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LF7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lf7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:12033936</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ginell, S.]]
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[[Category: Large Structures]]
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[[Category: Lebioda, L.]]
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[[Category: Ginell S]]
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[[Category: Minor, W.]]
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[[Category: Lebioda L]]
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[[Category: Ortlund, E.]]
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[[Category: Minor W]]
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[[Category: Parker, C L.]]
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[[Category: Ortlund E]]
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[[Category: Schreck, S F.]]
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[[Category: Parker CL]]
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[[Category: Sodetz, J M.]]
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[[Category: Schreck SF]]
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[[Category: Beta barrel]]
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[[Category: Sodetz JM]]
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[[Category: Calyx]]
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[[Category: Complement]]
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[[Category: Lipocalin]]
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[[Category: Mac]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:56:50 2009''
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Current revision

Crystal Structure of Human Complement Protein C8gamma at 1.2 A Resolution

PDB ID 1lf7

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