1uap

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{{Seed}}
 
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[[Image:1uap.png|left|200px]]
 
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==NMR structure of the NTR domain from human PCOLCE1==
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The line below this paragraph, containing "STRUCTURE_1uap", creates the "Structure Box" on the page.
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<StructureSection load='1uap' size='340' side='right'caption='[[1uap]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uap]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UAP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uap OCA], [https://pdbe.org/1uap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uap RCSB], [https://www.ebi.ac.uk/pdbsum/1uap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uap ProSAT]</span></td></tr>
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{{STRUCTURE_1uap| PDB=1uap | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCOC1_HUMAN PCOC1_HUMAN] Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ua/1uap_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uap ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Procollagen C-proteinase enhancer (PCOLCE) proteins are extracellular matrix proteins that enhance the activities of procollagen C-proteinases by binding to the C-propeptide of procollagen I. PCOLCE proteins are built of three structural modules, consisting of two CUB domains followed by a C-terminal netrin-like (NTR) domain. While the enhancement of proteinase activity can be ascribed solely to the CUB domains, sequence homology of the NTR domain with tissue inhibitors of metalloproteinases suggest proteinase inhibitory activity for the NTR domain. Here we present the three-dimensional structure of the NTR domain of human PCOLCE1 as the first example of a structural domain with the canonical features of an NTR module. The structure rules out a binding mode to metalloproteinases similar to that of tissue inhibitors of metalloproteinases but suggests possible inhibitory function toward specific serine proteinases. Sequence conservation between 13 PCOLCE proteins from different organisms suggests a conserved binding surface for other protein partners.
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===NMR structure of the NTR domain from human PCOLCE1===
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NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding.,Liepinsh E, Banyai L, Pintacuda G, Trexler M, Patthy L, Otting G J Biol Chem. 2003 Jul 11;278(28):25982-9. Epub 2003 Apr 1. PMID:12670942<ref>PMID:12670942</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12670942}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1uap" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12670942 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12670942}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1UAP is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UAP OCA].
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==Reference==
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<ref group="xtra">PMID:12670942</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Banyai, L.]]
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[[Category: Large Structures]]
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[[Category: Liepinsh, E.]]
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[[Category: Banyai L]]
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[[Category: Otting, G.]]
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[[Category: Liepinsh E]]
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[[Category: Patthy, L.]]
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[[Category: Otting G]]
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[[Category: Pintacuda, G.]]
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[[Category: Patthy L]]
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[[Category: Trexler, M.]]
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[[Category: Pintacuda G]]
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[[Category: Beta barrel]]
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[[Category: Trexler M]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:58:59 2009''
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Current revision

NMR structure of the NTR domain from human PCOLCE1

PDB ID 1uap

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OCA

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