1wmv

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{{Seed}}
 
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[[Image:1wmv.png|left|200px]]
 
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<!--
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==Solution structure of the second WW domain of WWOX==
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The line below this paragraph, containing "STRUCTURE_1wmv", creates the "Structure Box" on the page.
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<StructureSection load='1wmv' size='340' side='right'caption='[[1wmv]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wmv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WMV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wmv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmv OCA], [https://pdbe.org/1wmv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wmv RCSB], [https://www.ebi.ac.uk/pdbsum/1wmv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wmv ProSAT]</span></td></tr>
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{{STRUCTURE_1wmv| PDB=1wmv | SCENE= }}
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</table>
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== Disease ==
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===Solution structure of the second WW domain of WWOX===
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[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Note=Defects in WWOX may be involved in several cancer types. The gene spans the second most common chromosomal fragile site (FRA16D) which is frequently altered in cancers. Alteration of the expression and expression of some isoforms is associated with cancers. However, it is still unclear if alteration of WWOX is directly implicated in cancerogenesis or if it corresponds to a secondary effect.<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref> Defects in WWOX may be a cause of esophageal cancer (ESCR) [MIM:[https://omim.org/entry/133239 133239].<ref>PMID:11572989</ref> <ref>PMID:15266310</ref> <ref>PMID:15073125</ref> <ref>PMID:15131042</ref> <ref>PMID:16223882</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/WWOX_HUMAN WWOX_HUMAN] Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.<ref>PMID:11719429</ref> <ref>PMID:15548692</ref> <ref>PMID:15070730</ref> <ref>PMID:16061658</ref> <ref>PMID:16219768</ref> <ref>PMID:19366691</ref> <ref>PMID:19465938</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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1WMV is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WMV OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wm/1wmv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wmv ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Booker, G W.]]
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[[Category: Large Structures]]
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[[Category: Colella, A.]]
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[[Category: Booker GW]]
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[[Category: Kowalski, K.]]
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[[Category: Colella A]]
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[[Category: Merkel, A L.]]
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[[Category: Kowalski K]]
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[[Category: Richards, R I.]]
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[[Category: Merkel AL]]
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[[Category: All-beta]]
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[[Category: Richards RI]]
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[[Category: Ww domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:03:11 2009''
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Current revision

Solution structure of the second WW domain of WWOX

PDB ID 1wmv

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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