1xok

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(New page: 200px<br /><applet load="1xok" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xok, resolution 3.00&Aring;" /> '''crystal structure of...)
Current revision (08:52, 14 February 2024) (edit) (undo)
 
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[[Image:1xok.gif|left|200px]]<br /><applet load="1xok" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xok, resolution 3.00&Aring;" />
 
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'''crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide'''<br />
 
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==Overview==
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==crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide==
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Alfalfa mosaic virus genomic RNAs are infectious only when the viral coat, protein binds to the RNA 3' termini. The crystal structure of an alfalfa, mosaic virus RNA-peptide complex reveals that conserved AUGC repeats and, Pro-Thr-x-Arg-Ser-x-x-Tyr coat protein amino acids cofold upon, interacting. Alternating AUGC residues have opposite orientation, and they, base pair in different adjacent duplexes. Localized RNA backbone reversals, stabilized by arginine-guanine interactions place the adenosines and, guanines in reverse order in the duplex. The results suggest that a, uniform, organized 3' conformation, similar to that found on viral RNAs, with transfer RNA-like ends, may be essential for replication.
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<StructureSection load='1xok' size='340' side='right'caption='[[1xok]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1xok]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Alfalfa_mosaic_virus_(strain_YSMV) Alfalfa mosaic virus (strain YSMV)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XOK FirstGlance]. <br>
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1XOK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with BR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XOK OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xok OCA], [https://pdbe.org/1xok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xok RCSB], [https://www.ebi.ac.uk/pdbsum/1xok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xok ProSAT]</span></td></tr>
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Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication., Guogas LM, Filman DJ, Hogle JM, Gehrke L, Science. 2004 Dec 17;306(5704):2108-11. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15604410 15604410]
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</table>
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[[Category: Single protein]]
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== Function ==
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[[Category: Filman, D.J.]]
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[https://www.uniprot.org/uniprot/CAPSD_AMVYS CAPSD_AMVYS] Capsid protein. Binds to the to the 3' end of the nonpolyadenylated viral RNA and is involved in viral RNA translation initiation. Probably binds RNA and plays a role in packaging (By similarity).
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[[Category: Gehrke, L.]]
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__TOC__
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[[Category: Guogas, L.M.]]
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</StructureSection>
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[[Category: Hogle, J.M.]]
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[[Category: Large Structures]]
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[[Category: BR]]
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[[Category: Filman DJ]]
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[[Category: alpha helix]]
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[[Category: Gehrke L]]
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[[Category: atypical rna duplex]]
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[[Category: Guogas LM]]
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[[Category: protein-rna complex]]
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[[Category: Hogle JM]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:14:21 2007''
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Current revision

crystal structure of alfalfa mosaic virus RNA 3'UTR in complex with coat protein N terminal peptide

PDB ID 1xok

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