2b4e

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{{Seed}}
 
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[[Image:2b4e.png|left|200px]]
 
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==Crystal Structure of Murine Coronin-1: monoclinic form==
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The line below this paragraph, containing "STRUCTURE_2b4e", creates the "Structure Box" on the page.
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<StructureSection load='2b4e' size='340' side='right'caption='[[2b4e]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B4E FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b4e OCA], [https://pdbe.org/2b4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b4e RCSB], [https://www.ebi.ac.uk/pdbsum/2b4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b4e ProSAT]</span></td></tr>
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{{STRUCTURE_2b4e| PDB=2b4e | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COR1A_MOUSE COR1A_MOUSE] May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.<ref>PMID:10338208</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b4/2b4e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b4e ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mammalian coronin-1 is preferentially expressed in hematopoietic cells and plays a poorly understood role in the dynamic reorganization of the actin cytoskeleton. Sequence analysis of coronin-1 revealed five WD40 repeats that were predicted to form a beta propeller. They are followed by a 130 residue extension and a 30 residue leucine zipper domain that is responsible for multimerization of the protein. Here, we present the crystal structure of murine coronin-1 without the leucine zipper at 1.75 A resolution. Coronin-1 forms a seven-bladed beta propeller composed of the five predicted WD40 repeats and two additional blades that lack any homology to the canonical WD40 motif. The C-terminal extension adopts an extended conformation, packs tightly against the bottom surface of the propeller, and is likely to be required for the structural stability of the propeller. Analysis of charged and conserved surface residues delineate possible binding sites for F-actin on the beta propeller.
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===Crystal Structure of Murine Coronin-1: monoclinic form===
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The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes.,Appleton BA, Wu P, Wiesmann C Structure. 2006 Jan;14(1):87-96. PMID:16407068<ref>PMID:16407068</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_16407068}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2b4e" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16407068 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16407068}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2B4E is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B4E OCA].
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==Reference==
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<ref group="xtra">PMID:16407068</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Appleton, B A.]]
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[[Category: Appleton BA]]
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[[Category: Wiesmann, C.]]
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[[Category: Wiesmann C]]
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[[Category: Wu, P.]]
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[[Category: Wu P]]
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[[Category: 7-bladed beta-propeller]]
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[[Category: Wd40 repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:11:38 2009''
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Current revision

Crystal Structure of Murine Coronin-1: monoclinic form

PDB ID 2b4e

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