1sor

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{{Seed}}
 
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[[Image:1sor.png|left|200px]]
 
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==Aquaporin-0 membrane junctions reveal the structure of a closed water pore==
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The line below this paragraph, containing "STRUCTURE_1sor", creates the "Structure Box" on the page.
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<StructureSection load='1sor' size='340' side='right'caption='[[1sor]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SOR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron crystallography, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sor OCA], [https://pdbe.org/1sor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sor RCSB], [https://www.ebi.ac.uk/pdbsum/1sor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sor ProSAT]</span></td></tr>
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{{STRUCTURE_1sor| PDB=1sor | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIP_SHEEP MIP_SHEEP] Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.<ref>PMID:15141214</ref> <ref>PMID:15351655</ref> <ref>PMID:20389283</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/so/1sor_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sor ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The lens-specific water pore aquaporin-0 (AQP0) is the only aquaporin known to form membrane junctions in vivo. We show here that AQP0 from the lens core, containing some carboxy-terminally cleaved AQP0, forms double-layered crystals that recapitulate in vivo junctions. We present the structure of the AQP0 membrane junction as determined by electron crystallography. The junction is formed by three localized interactions between AQP0 molecules in adjoining membranes, mainly mediated by proline residues conserved in AQP0s from different species but not present in most other aquaporins. Whereas all previously determined aquaporin structures show the pore in an open conformation, the water pore is closed in AQP0 junctions. The water pathway in AQP0 also contains an additional pore constriction, not seen in other known aquaporin structures, which may be responsible for pore gating.
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===Aquaporin-0 membrane junctions reveal the structure of a closed water pore===
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Aquaporin-0 membrane junctions reveal the structure of a closed water pore.,Gonen T, Sliz P, Kistler J, Cheng Y, Walz T Nature. 2004 May 13;429(6988):193-7. PMID:15141214<ref>PMID:15141214</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1sor" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15141214}}, adds the Publication Abstract to the page
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*[[Aquaporin 3D structures|Aquaporin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15141214 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15141214}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1SOR is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SOR OCA].
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==Reference==
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<ref group="xtra">PMID:15141214</ref><references group="xtra"/>
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[[Category: Ovis aries]]
[[Category: Ovis aries]]
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[[Category: Cheng, Y.]]
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[[Category: Cheng Y]]
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[[Category: Gonen, T.]]
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[[Category: Gonen T]]
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[[Category: Kistler, J.]]
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[[Category: Kistler J]]
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[[Category: Sliz, P.]]
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[[Category: Sliz P]]
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[[Category: Walz, T.]]
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[[Category: Walz T]]
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[[Category: Membrane junction]]
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[[Category: Water channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:26:20 2009''
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Current revision

Aquaporin-0 membrane junctions reveal the structure of a closed water pore

PDB ID 1sor

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