1qyn

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{{Seed}}
 
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[[Image:1qyn.png|left|200px]]
 
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==Crystal Structure of SecB from Escherichia coli==
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The line below this paragraph, containing "STRUCTURE_1qyn", creates the "Structure Box" on the page.
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<StructureSection load='1qyn' size='340' side='right'caption='[[1qyn]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qyn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QYN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qyn OCA], [https://pdbe.org/1qyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qyn RCSB], [https://www.ebi.ac.uk/pdbsum/1qyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qyn ProSAT]</span></td></tr>
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{{STRUCTURE_1qyn| PDB=1qyn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SECB_ECOLI SECB_ECOLI] One of the proteins required for the normal export of some preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. Its substrates include AmpC, DegP, FhuA, FkpA, GBP, LamB, MalE (MBP), OmpA, OmpF, OmpT, OmpX, OppA, PhoE, TolB, TolC, YbgF, YcgK, YgiW and YncE.[HAMAP-Rule:MF_00821]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qy/1qyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qyn ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The chaperone SecB from Escherichia coli is primarily involved in passing precursor proteins into the Sec system via specific interactions with SecA. The crystal structure of SecB from E. coli has been solved to 2.35 A resolution. The structure shows flexibility in the crossover loop and the helix-connecting loop, regions that have been implicated to be part of the SecB substrate-binding site. Moreover conformational variability of Trp36 is observed as well as different loop conformations for the different monomers. Based on this, we speculate that SecB can regulate the access or extent of its hydrophobic substrate-binding site, by modulating the conformation of the crossover loop and the helix-connecting loop. The structure also clearly explains why the tetrameric equilibrium is shifted towards the dimeric state in the mutant SecBCys76Tyr. The buried cysteine residue is crucial for tight packing, and mutations are likely to disrupt the tetramer formation but not the dimer formation.
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===Crystal Structure of SecB from Escherichia coli===
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Crystal structure of SecB from Escherichia coli.,Dekker C, de Kruijff B, Gros P J Struct Biol. 2003 Dec;144(3):313-9. PMID:14643199<ref>PMID:14643199</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_14643199}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1qyn" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 14643199 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14643199}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1QYN is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QYN OCA].
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==Reference==
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<ref group="xtra">PMID:14643199</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Dekker, C.]]
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[[Category: Large Structures]]
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[[Category: Gros, P.]]
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[[Category: Dekker C]]
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[[Category: Kruijff, B de.]]
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[[Category: Gros P]]
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[[Category: Greek key beta sheet]]
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[[Category: De Kruijff B]]
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[[Category: Tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:28:47 2009''
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Current revision

Crystal Structure of SecB from Escherichia coli

PDB ID 1qyn

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