1hjd

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{{Seed}}
 
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[[Image:1hjd.png|left|200px]]
 
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==Melanoma inhibitory activity (MIA) protein==
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The line below this paragraph, containing "STRUCTURE_1hjd", creates the "Structure Box" on the page.
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<StructureSection load='1hjd' size='340' side='right'caption='[[1hjd]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hjd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HJD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hjd OCA], [https://pdbe.org/1hjd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hjd RCSB], [https://www.ebi.ac.uk/pdbsum/1hjd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hjd ProSAT]</span></td></tr>
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{{STRUCTURE_1hjd| PDB=1hjd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MIA_HUMAN MIA_HUMAN] Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/1hjd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hjd ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma, as enhanced values diagnose metastatic melanoma stages III and IV. Here we show that the recombinant human MIA adopts an SH3 domain-like fold in solution, with two perpendicular, antiparallel, three- and five-stranded beta-sheets. In contrast to known structures with the SH3 domain fold, MIA is a single-domain protein, and contains an additional antiparallel beta-sheet and two disulfide bonds. MIA is also the first extracellular protein found to have the SH3 domain-like fold. Furthermore, we show that MIA interacts with fibronectin and that the peptide ligands identified for MIA exhibit a matching sequence to type III human fibronectin repeats, especially to FN14, which is close to an integrin alpha4beta1 binding site. The present study, therefore, may explain the role of MIA in metastasis in vivo, and supports a model in which the binding of human MIA to type III repeats of fibronectin competes with integrin binding, thus detaching cells from the extracellular matrix.
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===MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN===
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The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold.,Stoll R, Renner C, Zweckstetter M, Bruggert M, Ambrosius D, Palme S, Engh RA, Golob M, Breibach I, Buettner R, Voelter W, Holak TA, Bosserhoff AK EMBO J. 2001 Feb 1;20(3):340-9. PMID:11157741<ref>PMID:11157741</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_11157741}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1hjd" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 11157741 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_11157741}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1HJD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HJD OCA].
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==Reference==
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<ref group="xtra">PMID:11157741</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bosserhoff, A K.]]
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[[Category: Large Structures]]
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[[Category: Holak, T A.]]
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[[Category: Bosserhoff AK]]
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[[Category: Stoll, R.]]
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[[Category: Holak TA]]
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[[Category: Voelter, W.]]
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[[Category: Stoll R]]
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[[Category: Growth factor]]
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[[Category: Voelter W]]
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[[Category: Signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:35:29 2009''
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Current revision

Melanoma inhibitory activity (MIA) protein

PDB ID 1hjd

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