1yrf

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{{Seed}}
 
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[[Image:1yrf.png|left|200px]]
 
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==Chicken villin subdomain HP-35, N68H, pH6.7==
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The line below this paragraph, containing "STRUCTURE_1yrf", creates the "Structure Box" on the page.
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<StructureSection load='1yrf' size='340' side='right'caption='[[1yrf]], [[Resolution|resolution]] 1.07&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yrf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YRF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.07&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1yrf| PDB=1yrf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yrf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrf OCA], [https://pdbe.org/1yrf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yrf RCSB], [https://www.ebi.ac.uk/pdbsum/1yrf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VILI_CHICK VILI_CHICK] Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.<ref>PMID:3793760</ref> <ref>PMID:1618806</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/1yrf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrf ConSurf].
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<div style="clear:both"></div>
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===Chicken villin subdomain HP-35, N68H, pH6.7===
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==See Also==
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*[[Villin|Villin]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15894611}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15894611 is the PubMed ID number.
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</StructureSection>
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[[Category: Gallus gallus]]
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{{ABSTRACT_PUBMED_15894611}}
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[[Category: Large Structures]]
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[[Category: Chiu TK]]
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==About this Structure==
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[[Category: Davies DR]]
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1YRF is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRF OCA].
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[[Category: Eaton WA]]
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[[Category: Herbst-Irmer R]]
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==Reference==
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[[Category: Hofrichter J]]
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<ref group="xtra">PMID:15894611</ref><references group="xtra"/>
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[[Category: Kubelka J]]
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[[Category: Chiu, T K.]]
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[[Category: Davies, D R.]]
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[[Category: Eaton, W A.]]
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[[Category: Herbst-Irmer, R.]]
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[[Category: Hofrichter, J.]]
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[[Category: Kubelka, J.]]
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[[Category: Villin headpiece subdomain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:36:29 2009''
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Current revision

Chicken villin subdomain HP-35, N68H, pH6.7

PDB ID 1yrf

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