1qkl

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{{Seed}}
 
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[[Image:1qkl.png|left|200px]]
 
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==hRPABC14.4, essential subunit of human RNA polymerases I, II and III==
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The line below this paragraph, containing "STRUCTURE_1qkl", creates the "Structure Box" on the page.
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<StructureSection load='1qkl' size='340' side='right'caption='[[1qkl]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qkl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QKL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qkl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qkl OCA], [https://pdbe.org/1qkl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qkl RCSB], [https://www.ebi.ac.uk/pdbsum/1qkl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qkl ProSAT]</span></td></tr>
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{{STRUCTURE_1qkl| PDB=1qkl | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPAB2_HUMAN RPAB2_HUMAN] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).<ref>PMID:9852112</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qk/1qkl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1qkl ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The protein hRPABC14.4 is an essential subunit of human RNA polymerases I, II, and III and is required for the transcription of all human nuclear genes. The structure of hRPABC14.4 was determined by nuclear magnetic resonance spectroscopy. The protein fold comprises a highly conserved central domain forming two antiparallel alpha-helices flanked by the less conserved N- and C-terminal regions forming a five-stranded beta-sandwich. Amino acids from the two helices participate in the generation of a hydrophobic surface area which is conserved in all eukaryotic and archaeal homologous subunits, and likely constitutes a critical macromolecular interaction interface. The hRPABC14.4 structure accounts for mutagenesis results in Saccharomyces cerevisiae and provides a structural working model for elucidating the role of this subunit in the molecular architecture and function of the human nuclear RNA polymerases.
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===HRPABC14.4, ESSENTIAL SUBUNIT OF HUMAN RNA POLYMERASES I, II AND III===
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Solution structure of the hRPABC14.4 subunit of human RNA polymerases.,del Rio-Portilla F, Gaskell A, Gilbert D, Ladias JA, Wagner G Nat Struct Biol. 1999 Nov;6(11):1039-42. PMID:10542096<ref>PMID:10542096</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1qkl" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_10542096}}, adds the Publication Abstract to the page
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 10542096 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_10542096}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1QKL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QKL OCA].
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==Reference==
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<ref group="xtra">PMID:10542096</ref><references group="xtra"/>
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Delrio-Portilla, F.]]
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[[Category: Large Structures]]
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[[Category: Gaskell, A G.]]
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[[Category: Del Rio-Portilla F]]
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[[Category: Gilbert, D.]]
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[[Category: Gaskell AG]]
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[[Category: Ladias, J A.A.]]
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[[Category: Gilbert D]]
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[[Category: Wagner, G.]]
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[[Category: Ladias JAA]]
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[[Category: Rna polymerase]]
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[[Category: Wagner G]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:48:04 2009''
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Current revision

hRPABC14.4, essential subunit of human RNA polymerases I, II and III

PDB ID 1qkl

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