2vee

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{{Seed}}
 
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[[Image:2vee.png|left|200px]]
 
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==Structure of protoglobin from Methanosarcina acetivorans C2A==
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The line below this paragraph, containing "STRUCTURE_2vee", creates the "Structure Box" on the page.
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<StructureSection load='2vee' size='340' side='right'caption='[[2vee]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2vee]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VEE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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{{STRUCTURE_2vee| PDB=2vee | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vee OCA], [https://pdbe.org/2vee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vee RCSB], [https://www.ebi.ac.uk/pdbsum/2vee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vee ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8TLY9_METAC Q8TLY9_METAC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/2vee_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vee ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structural adaptability of the globin fold has been highlighted by the recent discovery of the 2-on-2 haemoglobins, of neuroglobin and cytoglobin. Protoglobin from Methanosarcina acetivorans C2A-a strictly anaerobic methanogenic Archaea-is, to the best of our knowledge, the latest entry adding new variability and functional complexity to the haemoglobin (Hb) superfamily. Here, we report the 1.3 A crystal structure of oxygenated M. acetivorans protoglobin, together with the first insight into its ligand-binding properties. We show that, contrary to all known globins, protoglobin-specific loops and an amino-terminal extension completely bury the haem within the protein matrix. Access of O(2), CO and NO to the haem is granted by the protoglobin-specific apolar tunnels reaching the haem distal site from locations at the B/G and B/E helix interfaces. Functionally, M. acetivorans dimeric protoglobin shows a selectivity ratio for O(2)/CO binding to the haem that favours O(2) ligation and anticooperativity in ligand binding. Both properties are exceptional within the Hb superfamily.
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===STRUCTURE OF PROTOGLOBIN FROM METHANOSARCINA ACETIVORANS C2A===
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Archaeal protoglobin structure indicates new ligand diffusion paths and modulation of haem-reactivity.,Nardini M, Pesce A, Thijs L, Saito JA, Dewilde S, Alam M, Ascenzi P, Coletta M, Ciaccio C, Moens L, Bolognesi M EMBO Rep. 2008 Feb;9(2):157-63. Epub 2008 Jan 11. PMID:18188182<ref>PMID:18188182</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_18188182}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2vee" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 18188182 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_18188182}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2VEE is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VEE OCA].
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==Reference==
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<ref group="xtra">PMID:18188182</ref><references group="xtra"/>
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[[Category: Methanosarcina acetivorans]]
[[Category: Methanosarcina acetivorans]]
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[[Category: Alam, M.]]
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[[Category: Alam M]]
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[[Category: Ascenzi, P.]]
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[[Category: Ascenzi P]]
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[[Category: Bolognesi, M.]]
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[[Category: Bolognesi M]]
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[[Category: Ciaccio, C.]]
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[[Category: Ciaccio C]]
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[[Category: Coletta, M.]]
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[[Category: Coletta M]]
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[[Category: Dewilde, S.]]
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[[Category: Dewilde S]]
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[[Category: Moens, L.]]
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[[Category: Moens L]]
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[[Category: Nardini, M.]]
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[[Category: Nardini M]]
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[[Category: Pesce, A.]]
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[[Category: Pesce A]]
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[[Category: Saito, J A.]]
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[[Category: Saito JA]]
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[[Category: Thijs, L.]]
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[[Category: Thijs L]]
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[[Category: Archaea protein]]
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[[Category: Hemoprotein structure]]
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[[Category: Methanogenesis]]
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[[Category: Protein matrix tunnel]]
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[[Category: Protoglobin]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:55:10 2009''
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Current revision

Structure of protoglobin from Methanosarcina acetivorans C2A

PDB ID 2vee

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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