1say

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{{Seed}}
 
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[[Image:1say.png|left|200px]]
 
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==L-ALANINE DEHYDROGENASE COMPLEXED WITH PYRUVATE==
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The line below this paragraph, containing "STRUCTURE_1say", creates the "Structure Box" on the page.
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<StructureSection load='1say' size='340' side='right'caption='[[1say]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1say]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SAY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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{{STRUCTURE_1say| PDB=1say | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1say FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1say OCA], [https://pdbe.org/1say PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1say RCSB], [https://www.ebi.ac.uk/pdbsum/1say PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1say ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O52942_PHOLP O52942_PHOLP]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1say_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1say ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
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===L-ALANINE DEHYDROGENASE COMPLEXED WITH PYRUVATE===
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Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase.,Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:9665169<ref>PMID:9665169</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_9665169}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1say" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 9665169 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_9665169}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1SAY is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAY OCA].
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==Reference==
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<ref group="xtra">PMID:9665169</ref><references group="xtra"/>
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[[Category: Alanine dehydrogenase]]
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[[Category: Phormidium lapideum]]
[[Category: Phormidium lapideum]]
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[[Category: Baker, P J.]]
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[[Category: Baker PJ]]
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[[Category: Rice, D W.]]
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[[Category: Rice DW]]
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[[Category: Sawa, Y.]]
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[[Category: Sawa Y]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Sedelnikova SE]]
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[[Category: Shibata, H.]]
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[[Category: Shibata H]]
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[[Category: Nad]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:56:36 2009''
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Current revision

L-ALANINE DEHYDROGENASE COMPLEXED WITH PYRUVATE

PDB ID 1say

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