2gte

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{{Seed}}
 
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[[Image:2gte.png|left|200px]]
 
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==Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate==
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The line below this paragraph, containing "STRUCTURE_2gte", creates the "Structure Box" on the page.
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<StructureSection load='2gte' size='340' side='right'caption='[[2gte]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gte]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GTE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VA:(Z)-OCTADEC-11-ENYL+ACETATE'>VA</scene></td></tr>
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{{STRUCTURE_2gte| PDB=2gte | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gte OCA], [https://pdbe.org/2gte PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gte RCSB], [https://www.ebi.ac.uk/pdbsum/2gte PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gte ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OB76A_DROME OB76A_DROME] Odorant-binding protein required for olfactory behavior and for activity of pheromone-sensitive neurons. Binds to alcohols and mediates avoidance behavior to high concentrations of alcohols, the alcohol-binding possibly resulting in activation of receptors on T2B neurons, the activation of these receptors inhibiting these neurons. Acts in concert with Snmp and lush to capture cVA molecules on the surface of Or67d expressing olfactory dendrites and facilitate their transfer to the odorant-receptor Orco complex. Required for cVA response, probably by binding to VA. May act by serving as an adapter that bridges the presence of gaseous pheromone molecules, cVA, to activation of specific neuronal receptors expressed on T1 olfactory neurons, possibly via a specific conformational change induced by cVA that in turn activates T1 receptors. T1 neurons are excited by the pheromone VA, while T2 neurons are inhibited by alcohols. Also binds to phthalates.<ref>PMID:9755202</ref> <ref>PMID:11238251</ref> <ref>PMID:14759510</ref> <ref>PMID:15664171</ref> <ref>PMID:16928861</ref> <ref>PMID:17943085</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gt/2gte_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gte ConSurf].
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<div style="clear:both"></div>
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===Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate===
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==See Also==
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*[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18585358 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18585358}}
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==About this Structure==
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2GTE is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTE OCA].
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==Reference==
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<ref group="xtra">PMID:18585358</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Ha, T.]]
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[[Category: Large Structures]]
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[[Category: Jones, D N.M.]]
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[[Category: Ha T]]
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[[Category: Laughlin, J D.]]
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[[Category: Jones DNM]]
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[[Category: Smith, D P.]]
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[[Category: Laughlin JD]]
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[[Category: Odorant binding protein]]
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[[Category: Smith DP]]
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[[Category: Pheromone]]
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[[Category: Pheromone binding protein]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:06:43 2009''
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Current revision

Drosophila OBP LUSH bound to attractant pheromone 11-cis-vaccenyl acetate

PDB ID 2gte

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