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1ot7

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{{Seed}}
 
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[[Image:1ot7.png|left|200px]]
 
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==Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR==
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The line below this paragraph, containing "STRUCTURE_1ot7", creates the "Structure Box" on the page.
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<StructureSection load='1ot7' size='340' side='right'caption='[[1ot7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ot7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OT7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CHC:6-ETHYL-CHENODEOXYCHOLIC+ACID'>CHC</scene>, <scene name='pdbligand=IU5:ISO-URSODEOXYCHOLIC+ACID'>IU5</scene></td></tr>
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{{STRUCTURE_1ot7| PDB=1ot7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ot7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ot7 OCA], [https://pdbe.org/1ot7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ot7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ot7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ot7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H4_RAT NR1H4_RAT] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ot/1ot7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ot7 ConSurf].
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<div style="clear:both"></div>
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===Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR===
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==See Also==
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*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12718893}}, adds the Publication Abstract to the page
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[[Category: Homo sapiens]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12718893 is the PubMed ID number.
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_12718893}}
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==About this Structure==
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1OT7 is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OT7 OCA].
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==Reference==
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<ref group="xtra">PMID:12718893</ref><references group="xtra"/>
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Devarakonda, S.]]
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[[Category: Devarakonda S]]
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[[Category: Han, Q.]]
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[[Category: Han Q]]
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[[Category: Harp, J M.]]
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[[Category: Harp JM]]
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[[Category: Khorasanizadeh, S.]]
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[[Category: Khorasanizadeh S]]
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[[Category: Mi, L Z.]]
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[[Category: Mi LZ]]
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[[Category: Pellicciari, R.]]
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[[Category: Pellicciari R]]
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[[Category: Rastinejad, F.]]
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[[Category: Rastinejad F]]
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[[Category: Willson, T M.]]
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[[Category: Willson TM]]
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[[Category: Bile acid]]
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[[Category: Coactivator]]
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[[Category: Fxr]]
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[[Category: Ligand binding domain]]
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[[Category: Nuclear receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:10:39 2009''
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Current revision

Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR

PDB ID 1ot7

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