1yrk

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{{Seed}}
 
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[[Image:1yrk.png|left|200px]]
 
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==The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain==
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The line below this paragraph, containing "STRUCTURE_1yrk", creates the "Structure Box" on the page.
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<StructureSection load='1yrk' size='340' side='right'caption='[[1yrk]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1yrk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YRK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_1yrk| PDB=1yrk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yrk OCA], [https://pdbe.org/1yrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yrk RCSB], [https://www.ebi.ac.uk/pdbsum/1yrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yrk ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yr/1yrk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yrk ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.
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===The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain===
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C2 can do it, too.,Sondermann H, Kuriyan J Cell. 2005 Apr 22;121(2):158-60. PMID:15851022<ref>PMID:15851022</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1yrk" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15851022}}, adds the Publication Abstract to the page
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*[[Protein kinase C 3D structures|Protein kinase C 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15851022 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15851022}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1YRK is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YRK OCA].
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==Reference==
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<ref group="xtra">PMID:15851022</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Benes, C H.]]
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[[Category: Large Structures]]
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[[Category: Cantley, L C.]]
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[[Category: Benes CH]]
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[[Category: Dharia, T.]]
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[[Category: Cantley LC]]
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[[Category: Elia, A E.]]
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[[Category: Dharia T]]
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[[Category: Soltoff, S P.]]
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[[Category: Elia AE]]
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[[Category: Wu, N.]]
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[[Category: Soltoff SP]]
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[[Category: C2 domain]]
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[[Category: Wu N]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:33:47 2009''
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Current revision

The C2 Domain of PKC<delta> is a new Phospho-Tyrosine Binding Domain

PDB ID 1yrk

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