1xzz

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(New page: 200px<br /><applet load="1xzz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xzz, resolution 1.80&Aring;" /> '''Crystal structure of...)
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[[Image:1xzz.gif|left|200px]]<br /><applet load="1xzz" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1xzz, resolution 1.80&Aring;" />
 
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'''Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor'''<br />
 
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==Overview==
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==Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor==
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Binding of inositol 1,4,5-trisphosphate (IP(3)) to the amino-terminal, region of IP(3) receptor promotes Ca(2+) release from the endoplasmic, reticulum. Within the amino terminus, the first 220 residues directly, preceding the IP(3) binding core domain play a key role in IP(3) binding, suppression and regulatory protein interaction. Here we present a crystal, structure of the suppressor domain of the mouse type 1 IP(3) receptor at, 1.8 A. Displaying a shape akin to a hammer, the suppressor region contains, a Head subdomain forming the beta-trefoil fold and an Arm subdomain, possessing a helix-turn-helix structure. The conserved region on the Head, subdomain appeared to interact with the IP(3) binding core domain and is, in close proximity to the previously proposed binding sites of Homer, RACK1, calmodulin, and CaBP1. The present study sheds light onto the, mechanism underlying the receptor's sensitivity to the ligand and its, communication with cellular signaling proteins.
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<StructureSection load='1xzz' size='340' side='right'caption='[[1xzz]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1xzz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XZZ FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xzz OCA], [https://pdbe.org/1xzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xzz RCSB], [https://www.ebi.ac.uk/pdbsum/1xzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xzz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITPR1_MOUSE ITPR1_MOUSE] Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.<ref>PMID:2554142</ref> <ref>PMID:19752026</ref> <ref>PMID:20813840</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xz/1xzz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xzz ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1XZZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XZZ OCA].
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*[[Inositol 1%2C4%2C5-Trisphosphate Receptor|Inositol 1%2C4%2C5-Trisphosphate Receptor]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor., Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M, Mol Cell. 2005 Jan 21;17(2):193-203. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15664189 15664189]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Bosanac I]]
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[[Category: Bosanac, I.]]
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[[Category: Ikura M]]
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[[Category: Ikura, M.]]
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[[Category: Matsu-ura T]]
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[[Category: Matsu-ura, T.]]
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[[Category: Michikawa T]]
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[[Category: Michikawa, T.]]
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[[Category: Mikoshiba K]]
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[[Category: Mikoshiba, K.]]
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[[Category: Yamazaki H]]
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[[Category: Yamazaki, H.]]
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[[Category: GOL]]
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[[Category: b-trefoil fold]]
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[[Category: calcium channel]]
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[[Category: ip3 receptor]]
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[[Category: ip3 receptor suppressor domain]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 06:27:57 2007''
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Current revision

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor

PDB ID 1xzz

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