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1dgb

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{{Seed}}
 
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[[Image:1dgb.png|left|200px]]
 
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<!--
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==HUMAN ERYTHROCYTE CATALASE==
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The line below this paragraph, containing "STRUCTURE_1dgb", creates the "Structure Box" on the page.
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<StructureSection load='1dgb' size='340' side='right'caption='[[1dgb]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dgb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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{{STRUCTURE_1dgb| PDB=1dgb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgb OCA], [https://pdbe.org/1dgb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgb RCSB], [https://www.ebi.ac.uk/pdbsum/1dgb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgb ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[https://omim.org/entry/614097 614097]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dg/1dgb_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dgb ConSurf].
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<div style="clear:both"></div>
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===HUMAN ERYTHROCYTE CATALASE===
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==See Also==
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*[[Catalase 3D structures|Catalase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_10656833}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 10656833 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_10656833}}
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==About this Structure==
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1DGB is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGB OCA].
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==Reference==
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<ref group="xtra">PMID:10656833</ref><references group="xtra"/>
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[[Category: Catalase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arvai, A S.]]
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[[Category: Large Structures]]
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[[Category: Bourne, Y.]]
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[[Category: Arvai AS]]
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[[Category: Putnam, C D.]]
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[[Category: Bourne Y]]
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[[Category: Tainer, J A.]]
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[[Category: Putnam CD]]
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[[Category: Catalase]]
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[[Category: Tainer JA]]
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[[Category: Heme]]
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[[Category: Hydrogen peroxide]]
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[[Category: Nadph]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:35:13 2009''
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Current revision

HUMAN ERYTHROCYTE CATALASE

PDB ID 1dgb

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