2b2v

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{{Seed}}
 
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[[Image:2b2v.png|left|200px]]
 
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==Crystal structure analysis of human CHD1 chromodomains 1 and 2 bound to histone H3 resi 1-15 MeK4==
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The line below this paragraph, containing "STRUCTURE_2b2v", creates the "Structure Box" on the page.
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<StructureSection load='2b2v' size='340' side='right'caption='[[2b2v]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2b2v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2V FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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{{STRUCTURE_2b2v| PDB=2b2v | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2v OCA], [https://pdbe.org/2b2v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2v RCSB], [https://www.ebi.ac.uk/pdbsum/2b2v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHD1_HUMAN CHD1_HUMAN] ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells.<ref>PMID:18042460</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b2/2b2v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b2v ConSurf].
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<div style="clear:both"></div>
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===Crystal structure analysis of human CHD1 chromodomains 1 and 2 bound to histone H3 resi 1-15 MeK4===
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==See Also==
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*[[Chromodomain-helicase-DNA-binding protein 3D structures|Chromodomain-helicase-DNA-binding protein 3D structures]]
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*[[Helicase 3D structures|Helicase 3D structures]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_16372014}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 16372014 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_16372014}}
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==About this Structure==
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2B2V is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2V OCA].
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==Reference==
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<ref group="xtra">PMID:16372014</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chruszcz, M.]]
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[[Category: Large Structures]]
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[[Category: Clines, K L.]]
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[[Category: Chruszcz M]]
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[[Category: Cymborowski, M.]]
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[[Category: Clines KL]]
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[[Category: IV, J F.Flanagan.]]
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[[Category: Cymborowski M]]
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[[Category: Khorasanizadeh, S.]]
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[[Category: Flanagan IV JF]]
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[[Category: Kim, Y.]]
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[[Category: Khorasanizadeh S]]
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[[Category: Mi, L Z.]]
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[[Category: Kim Y]]
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[[Category: Minor, W.]]
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[[Category: Mi L-Z]]
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[[Category: Rastinejad, F.]]
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[[Category: Minor W]]
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[[Category: Alpha helix linker]]
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[[Category: Rastinejad F]]
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[[Category: Chd]]
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[[Category: Chromodomain]]
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[[Category: Histone h3]]
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[[Category: Monomethyllysine]]
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[[Category: Three stranded antiparallel beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:42:17 2009''
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Current revision

Crystal structure analysis of human CHD1 chromodomains 1 and 2 bound to histone H3 resi 1-15 MeK4

PDB ID 2b2v

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