1ttx

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{{Seed}}
 
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[[Image:1ttx.png|left|200px]]
 
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==Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy==
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The line below this paragraph, containing "STRUCTURE_1ttx", creates the "Structure Box" on the page.
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<StructureSection load='1ttx' size='340' side='right'caption='[[1ttx]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ttx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TTX FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1ttx| PDB=1ttx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ttx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ttx OCA], [https://pdbe.org/1ttx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ttx RCSB], [https://www.ebi.ac.uk/pdbsum/1ttx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ttx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ONCO_HUMAN ONCO_HUMAN] Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tt/1ttx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ttx ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The aim of this research was to determine the structure of human beta-parvalbumin (109 amino acids) and to compare it with its paralog and ortholog proteins. The structure was determined in solution using multinuclear and multidimensional NMR methods and refined using substitution of the EF-hand Ca(2+) ion with a paramagnetic lanthanide. The resulting family of structures had a backbone rmsd of 0.50 A. Comparison with rat oncomodulin (X-ray, 1.3 A resolution) as well as with human (NMR, backbone rmsd of 0.49 A) and rat (X-ray, 2.0 A resolution) parvalbumins reveals small but reliable local differences, often but not always related to amino acid variability. The analysis of these structures has led us to propose an explanation for the different affinity for Ca(2+) between alpha- and beta-parvalbumins and between parvalbumins and calmodulins.
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===Solution Stucture of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy===
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Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs.,Babini E, Bertini I, Capozzi F, Del Bianco C, Hollender D, Kiss T, Luchinat C, Quattrone A Biochemistry. 2004 Dec 28;43(51):16076-85. PMID:15610002<ref>PMID:15610002</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1ttx" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15610002}}, adds the Publication Abstract to the page
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*[[Parvalbumin|Parvalbumin]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15610002 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15610002}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1TTX is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTX OCA].
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==Reference==
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<ref group="xtra">PMID:15610002</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Babini, E.]]
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[[Category: Large Structures]]
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[[Category: Bertini, I.]]
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[[Category: Babini E]]
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[[Category: Bianco, C Del.]]
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[[Category: Bertini I]]
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[[Category: Capozzi, F.]]
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[[Category: Capozzi F]]
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[[Category: Hollender, D.]]
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[[Category: Del Bianco C]]
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[[Category: Kiss, T.]]
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[[Category: Hollender D]]
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[[Category: Luchinat, C.]]
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[[Category: Kiss T]]
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[[Category: Quattrone, A.]]
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[[Category: Luchinat C]]
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[[Category: SPINE, Structural Proteomics in Europe.]]
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[[Category: Quattrone A]]
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[[Category: Calcium]]
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[[Category: Ef-hand]]
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[[Category: Lanthanide]]
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[[Category: Nmr]]
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[[Category: Oncomodulin]]
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[[Category: Spine]]
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[[Category: Structural genomic]]
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[[Category: Structural proteomics in europe]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:42:41 2009''
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Current revision

Solution Structure of human beta parvalbumin (oncomodulin) refined with a paramagnetism based strategy

PDB ID 1ttx

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