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2akz

From Proteopedia

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{{Seed}}
 
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[[Image:2akz.png|left|200px]]
 
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<!--
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==Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex==
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The line below this paragraph, containing "STRUCTURE_2akz", creates the "Structure Box" on the page.
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<StructureSection load='2akz' size='340' side='right'caption='[[2akz]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2akz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AKZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F:FLUORIDE+ION'>F</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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{{STRUCTURE_2akz| PDB=2akz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2akz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2akz OCA], [https://pdbe.org/2akz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2akz RCSB], [https://www.ebi.ac.uk/pdbsum/2akz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2akz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ENOG_HUMAN ENOG_HUMAN] Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/2akz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2akz ConSurf].
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<div style="clear:both"></div>
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===Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex===
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==See Also==
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*[[Enolase 3D structures|Enolase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16411755}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16411755 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16411755}}
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==About this Structure==
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2AKZ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AKZ OCA].
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==Reference==
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<ref group="xtra">PMID:16411755</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphopyruvate hydratase]]
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[[Category: Large Structures]]
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[[Category: Brewer, J M.]]
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[[Category: Brewer JM]]
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[[Category: Chai, G.]]
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[[Category: Chai G]]
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[[Category: Lovelace, L L.]]
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[[Category: Lovelace LL]]
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[[Category: Qin, J.]]
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[[Category: Qin J]]
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[[Category: Crystal structure]]
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[[Category: Enolase]]
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[[Category: Fluoride inhibition]]
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[[Category: Glycolysis]]
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[[Category: Isothermal titration calorimetry]]
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[[Category: Negative cooperativity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:45:53 2009''
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Current revision

Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex

PDB ID 2akz

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