1s3t

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{{Seed}}
 
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[[Image:1s3t.png|left|200px]]
 
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==BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1s3t", creates the "Structure Box" on the page.
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<StructureSection load='1s3t' size='340' side='right'caption='[[1s3t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1s3t]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Sporosarcina_pasteurii Sporosarcina pasteurii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S3T FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BO3:BORIC+ACID'>BO3</scene>, <scene name='pdbligand=CXM:N-CARBOXYMETHIONINE'>CXM</scene>, <scene name='pdbligand=KCX:LYSINE+NZ-CARBOXYLIC+ACID'>KCX</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1s3t| PDB=1s3t | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s3t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s3t OCA], [https://pdbe.org/1s3t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s3t RCSB], [https://www.ebi.ac.uk/pdbsum/1s3t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s3t ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/URE3_SPOPA URE3_SPOPA]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s3/1s3t_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s3t ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the complex of urease, a Ni-containing metalloenzyme, with boric acid was determined at 2.10 A resolution. The complex shows the unprecedented binding mode of the competitive inhibitor to the dinuclear metal center, with the B(OH)3 molecule bridging the Ni ions and leaving in place the bridging hydroxide. Boric acid can be considered a substrate analogue of urea, and the structure supports the proposal that the Ni-bridging hydroxide acts as the nucleophile in the enzymatic process of urea hydrolysis.
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===BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE===
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Molecular details of urease inhibition by boric acid: insights into the catalytic mechanism.,Benini S, Rypniewski WR, Wilson KS, Mangani S, Ciurli S J Am Chem Soc. 2004 Mar 31;126(12):3714-5. PMID:15038715<ref>PMID:15038715</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1s3t" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15038715}}, adds the Publication Abstract to the page
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*[[Urease 3D structures|Urease 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15038715 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15038715}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1S3T is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Sporosarcina_pasteurii Sporosarcina pasteurii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S3T OCA].
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==Reference==
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<ref group="xtra">PMID:15038715</ref><references group="xtra"/>
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[[Category: Sporosarcina pasteurii]]
[[Category: Sporosarcina pasteurii]]
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[[Category: Urease]]
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[[Category: Benini S]]
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[[Category: Benini, S.]]
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[[Category: Ciurli S]]
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[[Category: Ciurli, S.]]
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[[Category: Mangani S]]
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[[Category: Mangani, S.]]
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[[Category: Rypniewski WR]]
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[[Category: Rypniewski, W R.]]
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[[Category: Wilson KS]]
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[[Category: Wilson, K S.]]
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[[Category: Bacillus pasteurii]]
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[[Category: Borate]]
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[[Category: Metalloenzyme]]
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[[Category: Nickel]]
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[[Category: Urease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 14:46:00 2009''
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Current revision

BORATE INHIBITED BACILLUS PASTEURII UREASE CRYSTAL STRUCTURE

PDB ID 1s3t

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